U-PLEX Metabolic Group 1 (human) 87-Plex

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The U-PLEX Metabolic Group 1 (human) 87-plex is a panel of biomarkers (Table 1) that has been tested for multiplex compatibility and is fulfilled as a kit. The U-PLEX Metabolic Group 1 (human) 87-plex contains biomarkers related to the human metabolism. It is a mix of traditional metabolic markers, inflammatory biomarkers, and emerging biomarkers related to metabolic syndrome and other disorders. The U-PLEX Metabolic Group 1 (human) 87-Plex can be used for quantitative measurements in serum, plasma, or P800 plasma, and offers detection limits (LLODs) in the sub- to low pg/mL range. Custom subplexes of this panel can be easily created online using MSD’s U-PLEX Assay Designer.

Table 1. List of analytes and typical detection limits

Analyte	LLOD - ULOD	units
BAFF	0.05 - 500	pg/mL
BDNF	0.72 - 2,000	pg/mL
β-NGF	0.05 - 500	pg/mL
C-Peptide	14 - 7,610	pg/mL
CTACK	1.8 - 4,200	pg/mL
ENA-78	0.53 - 3,940	pg/mL
Eotaxin	3.2 - 4,840	pg/mL
Eotaxin-2	3.1 - 6,000	pg/mL
Eotaxin-3	7.3 - 21,400	pg/mL
EPO	1.8 - 20,000	pg/mL
FGF-21	2.8 - 8,230	pg/mL
FGF-23	0.75 - 3,000	pg/mL
FLT3L	0.49 - 6,000	pg/mL
Fractalkine	100 - 181,000	pg/mL
FSH	9.0 - 75,000	µIU/mL
G-CSF	1.6 - 20,400	pg/mL
Ghrelin (active)	13 - 7,160	pg/mL
Ghrelin (total)	1.7 - 2,710	pg/mL
GIP (active)	1.3 - 1,920	pg/mL
GIP (inactive)	27 - 12,500	pg/mL
GIP (total)	3.7 - 12,500	pg/mL
GLP-1 (active)	0.01 - 57	pM
GLP-1 (inactive)	1.5 - 576	pM
GLP-1 (total)	0.59 - 576	pM
Glucagon	0.13 - 156	pM
GM-CSF	0.12 - 9,440	pg/mL
GRO-α	0.25 - 2,500	pg/mL
I-309	6.8 - 3,000	pg/mL
IFN-α2a	4.0 - 42,400	pg/mL

Analyte	LLOD - ULOD	units
IFN-β	3.1 - 100,000	pg/mL
IFN-γ	1.7 - 17,000	pg/mL
IL-1RA	1.7 - 5,000	pg/mL
IL-1α	0.98 - 5,080	pg/mL
IL-1β	0.15 - 3,820	pg/mL
IL-2	0.70 - 1,940	pg/mL
IL-2Rα	10 - 55,000	pg/mL
IL-3	11 - 16,000	pg/mL
IL-4	0.08 - 2,060	pg/mL
IL-5	0.24 - 4,040	pg/mL
IL-6	0.33 - 1,980	pg/mL
IL-7	1.5 - 7,040	pg/mL
IL-8	0.15 - 2,210	pg/mL
IL-9	0.14 - 1,500	pg/mL
IL-10	0.14 - 3,720	pg/mL
IL-12/IL-23p40	2.8 - 21,000	pg/mL
IL-12p70	0.69 - 5,320	pg/mL
IL-13	3.1 - 1,920	pg/mL
IL-15	0.82 - 3,030	pg/mL
IL-16	6.6 - 21,500	pg/mL
IL-17A/F	1.8 - 18,400	pg/mL
IL-17A	2.6 - 23,400	pg/mL
IL-17C	2.2 - 20,000	pg/mL
IL-17D	4.8 - 40,000	pg/mL
IL-17E/IL-25	0.58 - 9,240	pg/mL
IL-17F	160 - 112,000	pg/mL
IL-18	2.5 - 42,000	pg/mL
IL-21	1.2 - 12,600	pg/mL
IL-22	0.13 - 3,420	pg/mL

Analyte	LLOD - ULOD	units
IL-23	1.4 - 21,600	pg/mL
IL-27	9.6 - 50,600	pg/mL
IL-29/IFN-λ1	1.2 - 11,800	pg/mL
IL-31	7.3 - 11,100	pg/mL
IL-33	0.59 - 10,300	pg/mL
Insulin	0.32 - 736	µIU/mL
IP-10	0.49 - 6,000	pg/mL
Leptin	14 - 47,500	pg/mL
Luteinizing Hormone (LH)	1.6 - 27,700	µIU/mL
MCP-1	0.74 - 6,560	pg/mL
MCP-2	0.11 - 2,000	pg/mL
MCP-4	7.5 - 3,800	pg/mL
M-CSF	0.29 - 2,000	pg/mL
MDC	8.4 - 20,100	pg/mL
MIF	4.3 - 27,000	pg/mL
MIP-1α	7.7 - 4,200	pg/mL
MIP-5	0.34 - 30,000	pg/mL
PP	0.19 - 1,830	pg/mL
Proinsulin	0.05 - 130	pM
PYY (total)	2.7 - 2,260	pg/mL
SDF-1α	280 - 103,000	pg/mL
TARC	0.51 - 2,240	pg/mL
TNF-α	0.51 - 3,650	pg/mL
TNF-β	0.47 - 4,320	pg/mL
TPO	19 - 40,400	pg/mL
TRAIL	0.66 - 10,000	pg/mL
TSLP	0.20 - 10,100	pg/mL
VEGF-A	2.0 - 4,920	pg/mL
YKL-40	0.39 - 5,000	pg/mL

Specifications
Documentation
References

Application(s)		Metabolic
Analyte(s)		BAFF, BDNF, β-NGF, C-Peptide, CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, FGF-21, FGF-23, FLT3L, Fractalkine, FSH, G-CSF, Ghrelin (active), Ghrelin (total), GIP (active), GIP (inactive), GIP (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, Insulin, IP-10, Leptin, Luteinizing Hormone (LH), MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-5, PP, Proinsulin, PYY (total), SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, TSLP, VEGF-A, YKL-40
Species		Human
Instrument(s)		SECTOR Imager 2400 , MESO SECTOR S 600MM , SECTOR Imager 6000 , MESO QuickPlex SQ 120MM , MESO QuickPlex SQ 120 , MESO SECTOR S 600
U-PLEX Group Compatibility		Metabolic Group 1
Plate Type		96-well
Sample Type		Serum, EDTA Plasma, P800 Plasma
Usage Statement		For Research Use Only. Not for use in diagnostic procedures.
Storage Statement(s)		Please refer to the product insert for the storage conditions of individual kit components.
Storage Condition		Multi-Component
Schedule B Code		3822.19.0000

Contact Information

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1-240-314-2795

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1-240-314-2798

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Company Headquarters
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Product Inserts		U-PLEX Metabolic Group 1 (human) Multiplex Insert
Datasheets		U-PLEX Human C-Peptide U-PLEX Human FGF-21 U-PLEX Human FGF-23 U-PLEX Human FSH U-PLEX Human Ghrelin (active) U-PLEX Human Ghrelin (total) U-PLEX Human GIP (active) View More
Product Highlights		U-PLEX Platform Highlights
SDS		Biotin-conjugated Antibodies Safety Data Sheet Diluent 10, Diluent 11, Diluent 12, Diluent 13, Diluent 15, Diluent 16 and Diluent 17 Diluent 50, Diluent 56, Diluent 61, Diluent 100, and Diluent 101 MSD Calibrators and Controls MSD GOLD Read Buffer B U-PLEX Linker Set

Title	Journal	Year
Islet Autoantibody Standardization Program: interlaboratory comparison of insulin autoantibody assay performance in 2018 and 2020 workshops Ilaria Marzinotto, David L Pittman, Alistair J K Williams, Anna E Long, Peter Achenbach, Michael Schlosser, Beena Akolkar, William E Winter, Vito Lampasona; participating laboratories	Diabetologia	2023
Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke Fiona Chapman, Sarah Jean Pour, Roman Wieczorek, Edgar Trelles Sticken, Jessica Budde, Karin Röwer, Sandra Otte, Elizabeth Mason, Lukasz Czekala, Thomas Nahde, Grant O’Connell, Liam Simms and Matthew Stevenson	Frontiers in Toxicology	2023
A phase 1 study of prophylactic anakinra to mitigate ICANS in patients with large B-cell lymphoma Paolo Strati, Andrew Jallouk, Qing Deng, Xubin Li, Lei Feng, Ryan Sun, Sherry Adkins, Swapna Johncy, Taylor Cain, Raphael E. Steiner, Sairah Ahmed, Dai Chihara, Luis E. Fayad, Swaminathan P. Iyer, Sandra Horowitz, Loretta J. Nastoupil, Ranjit Nair, Ahmed Hassan, Taher E. Daoud, Misha Hawkins, Maria A. Rodriguez, Elizabeth J. Shpall, Jeremy L. Ramdial, Partow Kebriaei, David S. Hong, Jason R. Westin, Sattva S. Neelapu, Michael R. Green	Blood Advances	2023
Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms Arvid Edén, Anna Grahn, Daniel Bremell, Anahit Aghvanyan, Pradeepthi Bathala, Dietmar Fuchs, Johanna Gostner, Lars Hagberg, Nelly Kanberg, Sunsanee Kanjananimmanont, Magnus Lindh, Salvia Misaghian, Staffan Nilsson, Michael Schöll, George Sigal, Erika Stentoft, Marie Studahl, Aylin Yilmaz, Mingyue Wang, Martin Stengelin, Henrik Zetterberg, Magnus Gisslén	JAMA Network Open	2022
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations Bing Sun, Norina Tang, Michael J. Peluso, Nikita S. Iyer, Leonel Torres, Joanna L. Donatelli, Sadie E. Munter, Christopher C. Nixon, Rachel L. Rutishauser, Isabel Rodriguez-Barraquer, Bryan Greenhouse, John D. Kelly, Jeffrey N. Martin, Steven G. Deeks, Timothy J. Henrich, and Lynn Pulliam	Cells	2021
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