Intracellular signaling is one of the most widely studied areas in biology. Extracellular information perceived at the surface of a cell must be translated into an intracellular response that involves a complex network of interwoven signaling cascades. These signaling events regulate cellular responses like proliferation, differentiation, secretion, and apoptosis. Signal transduction cascades are generally triggered by the binding of ligands, such as growth factors, cytokines, neurotransmitters, or hormones, to a receptor. These receptors transmit the stimulus to the interior of the cell, where the signal is amplified and directed through a signaling pathway.

 

MSD provides solutions to support and simplify your intracellular signaling needs. We offer singleplex and multiplex assays to measure phosphoproteins, GPCR-ligand binding proteins, and ubiquitinated proteins.