Cytokines and chemokines are small signaling proteins secreted primarily by immune cells. Their main function is to coordinate cell growth, proliferation, and differentiation. Cytokines and their receptors participate in a diverse array of functions including innate and adaptive immunity, inflammation, immune cell differentiation, angiogenesis, tumorigenesis, development, neurobiology, and viral pathogenesis. Dysregulation of cytokine expression is a cause of immunological and inflammatory diseases, as well as other disease conditions. Many different cell types secrete chemokines, most often to attract immune cells to the site of infection or injury during innate and adaptive immune responses.

 

MSD offers an extensive portfolio of singleplex and multiplex assays to support your cytokine and chemokine research needs.

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Title	Journal	Year
Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants Jumana Samara, Shirin Moossavi, Belal Alshaikh, Van A Ortega, Veronika Kuchařová Pettersen, Tahsin Ferdous, Suzie L Hoops, Amuchou Soraisham, Joseph Vayalumkal, Deonne Dersch-Mills, Jeffrey S Gerber, Sagori Mukhopadhyay, Karen Puopolo, Thomas A Tompkins, Dan Knights, Jens Walter, Harish Amin, Marie-Claire Arrieta	Cell Host & Microbe	2022
The inflammatory profile of cerebrospinal fluid, plasma, and saliva from patients with severe neuropathic pain and healthy controls-a pilot study Mika Jönsson, Björn Gerdle, Bijar Ghafouri, Emmanuel Bäckryd	BMC Neuroscience	2021
Early and late effects of maternal experience on hippocampal neurogenesis, microglia, and the circulating cytokine milieu Rand S. Eid, Jessica A. Chaiton, Stephanie E. Lieblich, Tamara S. Bodnar, Joanne Weinberg, Liisa A.M. Galea	Neurobiology of Aging	2019
Cytokine biomarkers in tear film for primary open-angle glaucoma Gupta D, Wen JC, Huebner JL, Stinnett S, Kraus VB, Tseng HC, Walsh M.	Clin Ophthalmol.	2017
A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling. McArthur HL, Diab A, Page DB, Yuan J, Solomon SB, Sacchini V, Comstock C, Durack JC, Maybody M, Sung J, Ginsberg A, Wong P, Barlas A, Dong Z, Zhao C, Blum B, Patil S, Neville D, Comen EA, Morris EA, Kotin A, Brogi E, Wen YH, Morrow M, Lacouture ME, Sharma P, Allison JP, Hudis CA, Wolchok JD, Norton L.	Clin Cancer Res.	2016
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