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U-PLEX CAR-T Cell Safety Combo 1 (human)

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U-PLEX Combos are multiplex assays that are related to a specific application. They have been assembled for ordering convenience. The U-PLEX CAR-T Cell Safety Combo 1 (human) contains assays for seven analytes related to CAR-T cell safety (Table 1). The assays can be used for quantitative measurements in the sample types listed in the "Specifications" tab below, and offer detection limits (LLODs) in the sub- to low pg/mL range.

Table 1. List of analytes and typical detection limits

Analyte	LLOD - ULOD	units
GM-CSF	0.12 – 9,440	pg/mL
IFN-γ	1.7 – 17,000	pg/mL
IL-1β	0.15 – 3,820	pg/mL
IL-6	0.33 – 1,980	pg/mL
IL-10	0.14 – 3,720	pg/mL
MCP-1	0.74 – 6,560	pg/mL
TNF-α	0.51 – 3,650	pg/mL

Specifications
Kit Contents
Documentation
References

Analyte(s)		GM-CSF, IFN-γ, IL-1β, IL-6, IL-10, MCP-1, TNF-α
Species		Human
Instrument(s)		SECTOR Imager 2400 , MESO QuickPlex SQ 120MM , MESO SECTOR S 600 , SECTOR Imager 6000 , MESO SECTOR S 600MM , MESO QuickPlex SQ 120
U-PLEX Group Compatibility		Biomarker Group 1
Plate Type		96-well
Sample Type		Cell Culture Supernatant, Plasma, Serum
Usage Statement		For Research Use Only. Not for use in diagnostic procedures.
Storage Statement(s)		Please refer to the product insert for the storage conditions of individual kit components.
Storage Condition		Multi-Component
Schedule B Code		3822.19.0000

Product Description	Storage	Quantity per Kit
U-PLEX Linker Set, 7-Assay (300 µL)	2-8 °C	1 each (1 vial)

U-PLEX Human IFN-γ Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human IL-1β Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human IL-6 Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human IL-10 Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human TNF-α Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human MCP-1 Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human GM-CSF Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

Calibrator 1	2-8 °C	1 vial (1 vial)

Calibrator 2	2-8 °C	1 vial (1 vial)

U-PLEX 7-Assay, 96-Well SECTOR Plate	2-8 °C	1 each (1 plate)

U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)

Diluent 3	≤-10 °C	1 bottle (8 mL)

Diluent 57	≤-10 °C	1 bottle (10 mL)

MSD GOLD Read Buffer B	RT	1 bottle (18 mL)

Product Description	Storage	Quantity per Kit
U-PLEX Linker Set, 7-Assay (1.8 mL)	2-8 °C	1 each (1 vial)

U-PLEX Human IFN-γ Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human IL-1β Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human IL-6 Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human IL-10 Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human TNF-α Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human MCP-1 Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human GM-CSF Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

Calibrator 1	2-8 °C	5 vial (1 vial)

Calibrator 2	2-8 °C	5 vial (1 vial)

U-PLEX 7-Assay, 96-Well SECTOR Plate	2-8 °C	5 each (1 plate)

U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)

Diluent 3	≤-10 °C	1 bottle (40 mL)

Diluent 57	≤-10 °C	1 bottle (50 mL)

MSD GOLD Read Buffer B	RT	1 bottle (90 mL)

Product Description	Storage	Quantity per Kit
U-PLEX Linker Set, 7-Assay (1.8 mL)	2-8 °C	5 each (1 vial)

U-PLEX Human IFN-γ Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human IL-1β Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human IL-6 Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human IL-10 Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human TNF-α Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human MCP-1 Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human GM-CSF Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

Calibrator 1	2-8 °C	25 vial (1 vial)

Calibrator 2	2-8 °C	25 vial (1 vial)

U-PLEX 7-Assay, 96-Well SECTOR Plate	2-8 °C	25 each (1 plate)

U-PLEX Stop Solution	2-8 °C	5 bottle (40 mL)

Diluent 3	≤-10 °C	5 bottle (40 mL)

Diluent 57	≤-10 °C	5 bottle (50 mL)

MSD GOLD Read Buffer B	RT	5 bottle (90 mL)

Related Products

Product Name	Applications	Species	Plate Type
U-PLEX CAR-T Cell Combo 2 (human)	Oncology & Cancer	Human	96-well
U-PLEX CAR-T Cell Efficacy Combo 1 (human)		Human	96-well
U-PLEX CAR-T Cell Exhaustion Combo 1 (human)		Human	96-well
U-PLEX CAR-T Cell Persistence Combo 1 (human)		Human	96-well

Order Details

Catalog No

Size

Price in USD

Qty

K15711K-1

1 plate size

$2,080.00

Planned: 3 Day Delivery

K15711K-2

5 plate size

$8,319.00

Planned: 3 Day Delivery

K15711K-4

25 plate size

$36,393.00

Planned: 3 Day Delivery

Contact Information

Meso Scale Japan 株式会社
電話: 03.6265.7384
〒107-0062
東京都港区南青山 1-1-1 新青山ビル西館１４階 Vistra　Japan内

Product Inserts		U-PLEX Biomarker Group 1 (human) Multiplex Insert
Datasheets		U-PLEX Human GM-CSF U-PLEX Human IFN-γ U-PLEX Human IL-10 U-PLEX Human IL-1β U-PLEX Human IL-6 U-PLEX Human MCP-1 U-PLEX Human TNF-α
Product Highlights		U-PLEX Platform Highlights
SDS		Biotin-conjugated Antibodies Safety Data Sheet Diluent 2, Diluent 3, Diluent 5, Diluent 7 and Diluent 8 Diluent 57, Diluent 58, and Diluent 59 MSD Calibrators and Controls MSD GOLD Read Buffer B U-PLEX Linker Set
Technical Notes		Design of biomarker multiplex assays to support research on CAR-T cell efficacy, safety, persistence and exhaustion
Scientific Posters		Multiplexed Cytokine Assessment of T-and NK-cell Responses to Tumor Cells: Parallel Assessment of Biomarkers Associated with Efficacy, Safety, and Persistence

Title	Journal	Year
Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke Fiona Chapman, Sarah Jean Pour, Roman Wieczorek, Edgar Trelles Sticken, Jessica Budde, Karin Röwer, Sandra Otte, Elizabeth Mason, Lukasz Czekala, Thomas Nahde, Grant O’Connell, Liam Simms and Matthew Stevenson	Frontiers in Toxicology	2023
A phase 1 study of prophylactic anakinra to mitigate ICANS in patients with large B-cell lymphoma Paolo Strati, Andrew Jallouk, Qing Deng, Xubin Li, Lei Feng, Ryan Sun, Sherry Adkins, Swapna Johncy, Taylor Cain, Raphael E. Steiner, Sairah Ahmed, Dai Chihara, Luis E. Fayad, Swaminathan P. Iyer, Sandra Horowitz, Loretta J. Nastoupil, Ranjit Nair, Ahmed Hassan, Taher E. Daoud, Misha Hawkins, Maria A. Rodriguez, Elizabeth J. Shpall, Jeremy L. Ramdial, Partow Kebriaei, David S. Hong, Jason R. Westin, Sattva S. Neelapu, Michael R. Green	Blood Advances	2023
Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms Arvid Edén, Anna Grahn, Daniel Bremell, Anahit Aghvanyan, Pradeepthi Bathala, Dietmar Fuchs, Johanna Gostner, Lars Hagberg, Nelly Kanberg, Sunsanee Kanjananimmanont, Magnus Lindh, Salvia Misaghian, Staffan Nilsson, Michael Schöll, George Sigal, Erika Stentoft, Marie Studahl, Aylin Yilmaz, Mingyue Wang, Martin Stengelin, Henrik Zetterberg, Magnus Gisslén	JAMA Network Open	2022
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations Bing Sun, Norina Tang, Michael J. Peluso, Nikita S. Iyer, Leonel Torres, Joanna L. Donatelli, Sadie E. Munter, Christopher C. Nixon, Rachel L. Rutishauser, Isabel Rodriguez-Barraquer, Bryan Greenhouse, John D. Kelly, Jeffrey N. Martin, Steven G. Deeks, Timothy J. Henrich, and Lynn Pulliam	Cells	2021
Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection Najmeh Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu, Shima Shahbaz, Wendy Sligl, Mohammed Osman, Demetrios J. Kutsogiannis, Erika MacIntyre, Conar R. O’Neil, Shokrollah Elahi	mBio	2021
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U-PLEX CAR-T Cell Safety Combo 1 (human)

Kit Contents for Catalog No. K15711K-1

Kit Contents for Catalog No. K15711K-2

Kit Contents for Catalog No. K15711K-4

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