Neurodegenerative disease is an umbrella term for a range of conditions, which primarily affect the neurons in the human brain. Neurons are the building blocks of the nervous system which includes the brain and spinal cord. Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and/or death of nerve cells. This causes problems with movement and mental functioning. Examples of neurodegenerative diseases include Parkinson’s, Alzheimer’s, and Huntington’s disease.

 

MSD provides solutions to support and simplify your neurodegeneration research needs. We offer singleplex and multiplex assays to measure biomarkers such as Aβ38 peptide, β-secretase, and Tau.

• Human
• Mouse
• Rat
• Non-human primate
• All Species

Title	Journal	Year
Toward a human brain extracellular vesicle atlas: Characteristics of extracellular vesicles from different brain regions, including small RNA and protein profiles Yiyao Huang, Tanina Arab, Ashley E. Russell, Emily R. Mallick, Rajini Nagaraj, Evan Gizzie, Javier Redding-Ochoa, Juan C. Troncoso, Olga Pletnikova, Andrey Turchinovich, David A. Routenberg, Kenneth W. Witwer	Interdisciplinary Medicine	2023
Elevation of neural injury markers in patients with neurologic sequelae after hospitalization for SARS-CoV-2 infection Michail Spanos, Sigal Shachar, Thadryan Sweeney, H Immo Lehmann, Priyanka Gokulnath, Guoping Li, George B Sigal, Rajini Nagaraj, Pradeepthi Bathala, Farhan Rana, Ravi V Shah, David A Routenberg, Saumya Das	iScience	2022
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations Bing Sun, Norina Tang, Michael J. Peluso, Nikita S. Iyer, Leonel Torres, Joanna L. Donatelli, Sadie E. Munter, Christopher C. Nixon, Rachel L. Rutishauser, Isabel Rodriguez-Barraquer, Bryan Greenhouse, John D. Kelly, Jeffrey N. Martin, Steven G. Deeks, Timothy J. Henrich, and Lynn Pulliam	Cells	2021
Leptin levels are associated with multiple sclerosis risk Biström M, Hultdin J, Andersen O, Alonso-Magdalena L, Jons D, Gunnarsson M, Vrethem M, Sundström P	Multiple Sclerosis	2020
CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer’s disease Jonathan D. Cherry , Thor D. Stein, Yorghos Tripodis, Victor E. Alvarez, Bertrand R. Huber, Rhoda Au, Patrick T. Kiernan, Daniel H. Daneshvar, Jesse Mez, Todd M. Solomon, Michael L. Alosco, Ann C. McKee	PLOS ONE	2017