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U-PLEX CAR-T Cell Combo 1 (human)

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U-PLEX Combos offer popular panels of biomarkers that have been grouped together for convenient ordering. They have been tested for multiplex compatibility and are fulfilled as a kit. The U-PLEX CAR-T Cell Combo 1 (human) combines 6 analytes (Table 1) that are associated with CAR-T cell activity. The assays can be used for quantitative measurements of the sample type(s) listed in the "Specifications" tab below, and offer detection limits (LLODs) in the sub- to low pg/mL range.

Table 1. List of analytes and typical detection limits

Analyte	LLOD - ULOD	Unit
GM-CSF	0.12 - 9,440	pg/mL
Granzyme A	0.49 - 3,700	pg/mL
Granzyme B	0.10 - 750	pg/mL
IFN-γ	1.7 - 17,000	pg/mL
IL-2	0.70 - 1,940	pg/mL
TNF-α	0.51 - 3,650	pg/mL

Specifications
Kit Contents
Documentation
References

Analyte(s)		GM-CSF, Granzyme A, Granzyme B, IFN-γ, IL-2, TNF-α
Species		Human
Instrument(s)		SECTOR Imager 2400 , MESO QuickPlex SQ 120MM , MESO SECTOR S 600 , SECTOR Imager 6000 , MESO SECTOR S 600MM , MESO QuickPlex SQ 120
U-PLEX Group Compatibility		Immuno-Oncology Group 1
Plate Type		96-well
Sample Type		Plasma, Serum
Usage Statement		For Research Use Only. Not for use in diagnostic procedures.
Storage Statement(s)		Please refer to the product insert for the storage conditions of individual kit components.
Storage Condition		Multi-Component
Schedule B Code		3822.19.0000

Product Description	Storage	Quantity per Kit
U-PLEX Linker Set, 6-Assay (300 µL)	2-8 °C	1 each (1 vial)

U-PLEX Human Granzyme B Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human IFN-γ Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human IL-2 Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human TNF-α Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human GM-CSF Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human Granzyme A Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

Calibrator 1	2-8 °C	1 vial (1 vial)

Calibrator 23	≤-70 °C	1 vial (1 vial)

U-PLEX 6-Assay, 96-Well SECTOR Plate	2-8 °C	1 each (1 plate)

U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)

Diluent 3	≤-10 °C	1 bottle (8 mL)

Diluent 58, 10 mL	≤-10 °C	1 bottle (10 mL)

MSD GOLD Read Buffer B	RT	1 bottle (18 mL)

Product Description	Storage	Quantity per Kit
U-PLEX Linker Set, 6-Assay (1.8 mL)	2-8 °C	1 each (1 vial)

U-PLEX Human Granzyme B Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human IFN-γ Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human IL-2 Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human TNF-α Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human GM-CSF Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human Granzyme A Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

Calibrator 1	2-8 °C	5 vial (1 vial)

Calibrator 23	≤-70 °C	5 vial (1 vial)

U-PLEX 6-Assay, 96-Well SECTOR Plate	2-8 °C	5 each (1 plate)

U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)

Diluent 3	≤-10 °C	1 bottle (40 mL)

Diluent 58	≤-10 °C	1 bottle (50 mL)

MSD GOLD Read Buffer B	RT	1 bottle (90 mL)

Product Description	Storage	Quantity per Kit
U-PLEX Linker Set, 6-Assay (1.8 mL)	2-8 °C	5 each (1 vial)

U-PLEX Human Granzyme B Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human IFN-γ Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human IL-2 Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human TNF-α Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human GM-CSF Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human Granzyme A Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

Calibrator 1	2-8 °C	25 vial (1 vial)

Calibrator 23	≤-70 °C	25 vial (1 vial)

U-PLEX 6-Assay, 96-Well SECTOR Plate	2-8 °C	25 each (1 plate)

U-PLEX Stop Solution	2-8 °C	5 bottle (40 mL)

Diluent 3	≤-10 °C	5 bottle (40 mL)

Diluent 58	≤-10 °C	5 bottle (50 mL)

MSD GOLD Read Buffer B	RT	5 bottle (90 mL)

Title	Journal	Year
Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke Fiona Chapman, Sarah Jean Pour, Roman Wieczorek, Edgar Trelles Sticken, Jessica Budde, Karin Röwer, Sandra Otte, Elizabeth Mason, Lukasz Czekala, Thomas Nahde, Grant O’Connell, Liam Simms and Matthew Stevenson	Frontiers in Toxicology	2023
Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms Arvid Edén, Anna Grahn, Daniel Bremell, Anahit Aghvanyan, Pradeepthi Bathala, Dietmar Fuchs, Johanna Gostner, Lars Hagberg, Nelly Kanberg, Sunsanee Kanjananimmanont, Magnus Lindh, Salvia Misaghian, Staffan Nilsson, Michael Schöll, George Sigal, Erika Stentoft, Marie Studahl, Aylin Yilmaz, Mingyue Wang, Martin Stengelin, Henrik Zetterberg, Magnus Gisslén	JAMA Network Open	2022
Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection Najmeh Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu, Shima Shahbaz, Wendy Sligl, Mohammed Osman, Demetrios J. Kutsogiannis, Erika MacIntyre, Conar R. O’Neil, Shokrollah Elahi	mBio	2021
Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, Xue Manz, Jurjan Aman, Amsterdam UMC COVID-19 Biobank, Peter Bonta, Philip Brouwer, Steven de Taeye, Tom Caniels, Karlijn van der Straten, Korneliusz Golebski, Guillermo Griffith, René Jonkers, Mads Larsen, Federica Linty, Annette Neele, Jan Nouta, Frank van Baarle, Cornelis van Drunen, Alexander Vlaar, Godelieve de Bree, Rogier Sanders, Lisa Willemsen, Manfred Wuhrer, Harm Jan Bogaard, Marit van Gils, Gestur Vidarsson, Menno de Winther, Jeroen den Dunnen	TBD	2020
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2 Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T. Fisher, Julie C. Fitzgerald, Jeffrey S. Gerber, Kandace Gollomp, Christopher Gray, Stephan A. Grupp, Rebecca M. Harris, Todd J. Kilbaugh, Audrey R. Odom John, Michele Lambert, Emily J. Liebling, Michele E. Paessler, Whitney Petrosa, Charles Phillips, Anne F. Reilly, Neil D. Romberg, Alix Seif, Deborah A. Sesok-Pizzini, Kathleen E. Sullivan, Julie Vardaro, Edward M. Behrens, David T. Teachey, Hamid Bassiri	The Journal of Clinical Investigation	2020
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Order Details

Catalog No

Size

Price in USD

Qty

K15338K-1

1 plate size

$1,826.00

Usually ships in 1-3 days

K15338K-2

5 plate size

$7,296.00

Usually ships in 1-3 days

K15338K-4

25 plate size

$31,923.00

Usually ships in 1-3 days

Contact Information

Meso Scale Japan 株式会社
電話: 03.6265.7384
〒107-0062
東京都港区南青山 1-1-1 新青山ビル西館１４階 Vistra　Japan内

Product Inserts		U-PLEX I-O Group 1 (human) Multiplex Insert
Datasheets		U-PLEX Human GM-CSF U-PLEX Human Granzyme A U-PLEX Human Granzyme B U-PLEX Human IFN-γ U-PLEX Human IL-2 U-PLEX Human TNF-α
Product Highlights		U-PLEX Platform Highlights
SDS		Biotin-conjugated Antibodies Safety Data Sheet Diluent 2, Diluent 3, Diluent 5, Diluent 7 and Diluent 8 Diluent 57, Diluent 58, and Diluent 59 MSD Calibrators and Controls MSD GOLD Read Buffer B U-PLEX Linker Set
Technical Notes		Design of biomarker multiplex assays to support research on CAR-T cell efficacy, safety, persistence and exhaustion

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U-PLEX CAR-T Cell Combo 1 (human)

Kit Contents for Catalog No. K15338K-1

Kit Contents for Catalog No. K15338K-2

Kit Contents for Catalog No. K15338K-4

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