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Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection.
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Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARg.
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Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection.
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Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.
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LPS-induced biomarkers in mice: a potential model for identifying insulin sensitizers.
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Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity.
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Multiplexing siRNAs to compress RNAi-based screen size in human cells.
Martin, S.E., Jones, T.L., Thomas, C.L., Lorenzi, P.L., Nguyen, D.A., Runfola, T., Gunsior, M., Weinstein, J.N., Goldsmith, P.K., Lader, E., Huppi, K., Caplen, N.J. | Nucleic Acids Res. | 2007 | View |
Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
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Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis.
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Patholocial activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Shirotani, K., Tomioka, M., Kremmer, E., Haass, C., Steiner, H. | Neurobiology of Disease | 2007 | View |
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
Hall, J.P., Kurdi Y., Hsu S., Cuozzo J., Liu J., Telliez J.B., Seidl K.J., Winkler, A., Hu, Y., Green, N., Askew, G.R., Tam, S., Clark, J.D., Lin, L.L. | J Biol Chem. | 2007 | View |
Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease.
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Pharmacological Characterization of a Potent Inhibitor of Class I Phosphotidylinositide 3-Kinases.
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Phosphorylation of APP695 at Thr668 decreases g-cleavage and extracellular Ab.
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Purification of soluble CD14 fusion proteins and the use in an electrochemiluminescent assay for lipopolysaccharide binding.
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Rab10 is Involved in Basolateral Transport in Polarized Madin-Darby Canine Kidney Cells.
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Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors.
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Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps.
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STAT3 Mutations in the Hyper-IgE Syndrome.
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Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines.
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The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.
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The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK.
Ronkina, N., Kotlyarov, A., Dittrich-Breiholz, O., Kracht, M., Hitti, E., Milarski, K. | Mol Cell Biol. | 2007 | View |
The Novel gamma-Secretase Inhibitor N-[cis-4-[(4- Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1- trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse.
Best, J.D., Smith, D.W., Reilly, M.A., O'Donnell, R., Lewis, H.D., Ellis, S., Wilkie, N., Rosahl, T.W., Laroque, P.A., Boussiquet-Leroux, C., Churcher, I., Atack, J.R., Harrison, T., Shearman, M.S. | J Pharmacol Exp Ther. | 2007 | View |
TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha.
Ghosh, T.K., Michelson, D.J., Solberg, J.C., Lipson, K.E., Inglefield, J.R., Alkan, S.S. | Int Immunopharmacol. | 2007 | View |
Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier.
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