A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study.

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A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study.

Hirata S, Dirven L, Shen Y, Centola M, Cavet G, Lems WF, Tanaka Y, Huizinga TW, Allaart CF.

Journal		Rheumatology (Oxford)
Species
Analytes Measured		CRP , EGF , IL-6 , Leptin , MMP-1 , MMP-3 total , Resistin , SAA , TNF-RI , VCAM-1 , Flt-1 VEGFR1 , YKL-40
Matrix Tested		Serum

Year		2013
Volume
Page Numbers
Application		Cytokines and Chemokines , Metabolic

Abstract

Objective: To evaluate a multi-biomarker disease activity (MBDA) score, a novel index based on 12 serum proteins, as a tool to guide management of RA patients.

Methods: A total of 125 patients with RA from the Behandel Strategieën study were studied. Clinical data and serum samples were available from 179 visits, 91 at baseline and 88 at year 1. In each serum sample, 12 biomarkers were measured by quantitative multiplex immunoassays and the concentrations were used as input to a pre-specified algorithm to calculate MBDA scores.

Results: MBDA scores had significant correlation with DAS28-ESR (Spearman's ρ = 0.66, P < 0.0001) and also correlated with simplified disease activity index, clinical disease activity index and HAQ Disability Index (all P < 0.0001). Changes in MBDA between baseline and year 1 were also correlated with changes in DAS28-ESR (ρ = 0.55, P < 0.0001). Groups stratified by European League Against Rheumatism disease activity (DAS28-ESR ≤ 3.2, 3.2-5.1 and > 5.1) had significantly different MBDA scores (P < 0.0001) and MBDA score could discriminate ACR/EULAR Boolean remission with an area under the receiver operating characteristic curve of 0.83 (P < 0.0001).

Conclusion: The MBDA score reflects current clinical disease activity and can track changes in disease activity over time.

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U-PLEX Obesity Combo 2 (rat) C-Peptide, Ghrelin (total), GLP-1 (total), Insulin, Leptin, PYY (total) \| Rat Multiplex		NEW
U-PLEX Obesity Combo 2 (mouse) C-Peptide, Ghrelin (total), GLP-1 (total), Insulin, Leptin, PYY (total) \| Mouse Multiplex		NEW
U-PLEX Obesity Combo 1 (rat) BDNF, FGF-21, Ghrelin (total), Glucagon, Leptin \| Rat Multiplex		NEW
U-PLEX Obesity Combo 1 (mouse) BDNF, FGF-21, Ghrelin (total), Glucagon, Leptin \| Mouse Multiplex		NEW
U-PLEX Obesity Combo 1 (human) BDNF, FGF-21, Ghrelin (total), Glucagon, Leptin \| Human Multiplex		NEW
U-PLEX Vascular Injury Combo 1 (human) CRP, Factor VII, ICAM-1, SAA, VCAM-1 \| Human Multiplex		NEW
U-PLEX TH17 Combo 2 (mouse) IFN-γ, IL-1β, IL-6, IL-17A, IL-17C, IL-17E/IL-25, IL-17F, IL-21, IL-22, TNF-α \| Mouse Multiplex		NEW
U-PLEX TH17 Combo 2 (human) IFN-γ, IL-1β, IL-6, IL-10, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, TNF-α \| Human Multiplex		NEW
U-PLEX TH17 Combo 1 (NHP) IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-17A, TNF-α \| Non-human primate Multiplex		NEW
U-PLEX TBI Combo 1 (human) CD40L (soluble), Fractalkine, IFN-γ, IL-1β, IL-6, IL-18, MCP-1, RANKL/TNFSF11, TNF-α, VEGF-D \| Human Multiplex		NEW
U-PLEX Proinflam Combo 4 (human) IL-1β, IL-6, IL-8, TNF-α \| Human Multiplex		NEW
U-PLEX Proinflam Combo 3 (human) IFN-γ, IL-1β, IL-6, TNF-α \| Human Multiplex		NEW
U-PLEX Proinflam Combo 2 (human) GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70 \| Human Multiplex		NEW
U-PLEX Proinflam Combo 1 (NHP) IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12/IL-23p40, TNF-α \| Non-human primate Multiplex		NEW
U-PLEX Proinflam Combo 1 (mouse) IFN-γ, IL-1β, IL-2, IL-6, IL-10, IL-12p70, IL-17A, IP-10, MCP-1, TNF-α \| Mouse Multiplex		NEW
U-PLEX Proinflam Combo 1 (human) IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-α \| Human Multiplex		NEW
U-PLEX Inflammation Combo 1 (human) Complement C9, Complement factor D, CRP, ICAM-1, NGAL/LCN2, SAA, VCAM-1 \| Human Multiplex		NEW
U-PLEX Viral Combo 1 (human) G-CSF, GM-CSF, IFN-α2a, IFN-β, IFN-γ, IL-1β, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IP-10, MCP-1, MIP-1α, TNF-α, VEGF-A \| Human Multiplex		NEW
U-PLEX Viral Combo 1 (NHP) G-CSF, GM-CSF, IFN-α2a, IFN-γ, IL-1β, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IP-10, MCP-1, MIP-1α, TNF-α, VEGF-A \| Non-human primate Multiplex		NEW
U-PLEX Macrophage M1 Combo 1 (human) QuickPlex (5 PL) IL-1β, IL-6, IL-12p70, IL-18, IL-23, IP-10, MCP-1, MIP-1α, TNF-α \| Human Multiplex		NEW
U-PLEX Inflammation Combo 1 (human) QuickPlex (5 PL) Complement C9, Complement factor D, CRP, ICAM-1, NGAL/LCN2, VCAM-1 \| Human Multiplex		NEW
U-PLEX Obesity Combo 2 (human) C-Peptide, FGF-23, Ghrelin (total), GLP-1 (total), Insulin, Leptin, PYY (total) \| Human Multiplex		NEW
U-PLEX Diabetes Combo 2 (human) C-Peptide, GIP (total), GLP-1 (active), Glucagon, Insulin, Leptin, PYY (total) \| Human Multiplex		NEW
S-PLEX Proinflammatory Panel 1 (human) Kit IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-17A, TNF-α \| Human Multiplex		NEW
R-PLEX Mouse YKL-40 Antibody Set YKL-40 \| Mouse
R-PLEX Mouse YKL-40 Assay YKL-40 \| Mouse Singleplex
R-PLEX Mouse EGF Antibody Set EGF \| Mouse
R-PLEX Mouse VCAM-1 Antibody Set VCAM-1 \| Mouse
R-PLEX Mouse EGF Assay EGF \| Mouse Singleplex
R-PLEX Mouse VCAM-1 Assay VCAM-1 \| Mouse Singleplex
U-PLEX Human MMP-1 Antibody Set MMP-1 \| Human
U-PLEX Human VEGFR-1/Flt-1 Antibody Set VEGFR-1/Flt-1 \| Human
U-PLEX Human TNF-RI Antibody Set TNF-RI \| Human
U-PLEX Human MMP-1 384-well Assay MMP-1 \| Human Singleplex
U-PLEX Human VEGFR-1/Flt-1 384-well Assay VEGFR-1/Flt-1 \| Human Singleplex
U-PLEX Human TNF-RI 384-well Assay TNF-RI \| Human Singleplex
U-PLEX Human MMP-1 Assay MMP-1 \| Human Singleplex
U-PLEX Human VEGFR-1/Flt-1 Assay VEGFR-1/Flt-1 \| Human Singleplex
U-PLEX Human TNF-RI Assay TNF-RI \| Human Singleplex
U-PLEX Mouse Leptin 384-Well Assay Leptin \| Mouse Singleplex
U-PLEX Rat Leptin 384-Well Assay Leptin \| Rat Singleplex
U-PLEX Human CRP 384-Well Assay CRP \| Human Singleplex
U-PLEX Human SAA 384-Well Assay SAA \| Human Singleplex
U-PLEX Human VCAM-1 384-Well Assay VCAM-1 \| Human Singleplex
U-PLEX Mouse IL-6 384-Well Assay IL-6 \| Mouse Singleplex
U-PLEX Mouse TNF-RI 384-Well Assay TNF-RI \| Mouse Singleplex
U-PLEX NHP IL-6 384-Well Assay IL-6 \| Non-human primate Singleplex
U-PLEX NHP YKL-40 384-Well Assay YKL-40 \| Non-human primate Singleplex
U-PLEX Custom Metabolic Group 1 (ms) 384-well Assays BAFF, BCA-1/BLC, BDNF, CD40/TNFRSF5, C-Peptide, Eotaxin, EPO, FGF-21, Ghrelin (active), Ghrelin (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, IFN-α, IFN-β, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27p28/IL-30, IL-31, IL-33, Insulin, IP-10, KC/GRO, Leptin, MCP-1, MCP-5/CCL12, MDC, MIP-1α, MIP-1β, MIP-2, MIP-3α, MMP-9 (total), PYY (total), RANTES, TARC, TNF-α, VEGF-A \| Mouse Multiplex
U-PLEX Custom Metabolic Group 1 (rat) 384-well Assays BDNF, C-Peptide, FGF-21, Ghrelin (active), Ghrelin (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, Insulin, Leptin, PYY (total) \| Rat Multiplex
U-PLEX Custom Biomarker Group 1 (mouse) 384-well Assays 6CKine/CCL21, BAFF, BCA-1/BLC, CD40/TNFRSF5, Eotaxin, EPO, GM-CSF, IFN-α, IFN-β, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27p28/IL-30, IL-31, IL-33, IP-10, KC/GRO, MCP-1, MCP-5/CCL12, MDC, MIP-1α, MIP-1β, MIP-2, MIP-3α, MMP-9 (total), NGAL/LCN2, RANTES, SDF-1α, TARC, TNF-α, TNF-RI, VEGF-A \| Mouse Multiplex
U-PLEX Biomarker Group 1 (NHP) 384-well Assays CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, FLT3L, Fractalkine, G-CSF, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, IL-17F, IL-18, IL-22, IL-23, IP-10, I-TAC, MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-1β, MIP-3α, MIP-3β, MIP-5, SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, VEGF-A, YKL-40 \| Non-human primate Multiplex
U-PLEX Custom Biomarker Group 3 (human) 384-well Assays A2M, Adiponectin, ApoA1, ApoC3, CA1, Clusterin, Complement C9, Complement factor D, CRP, Cystatin C, DPPIV, Factor VII, ICAM-1, NGAL/LCN2, RBP4, SAA, Serpin A1, SHBG, sTfR-1, VCAM-1, vWF \| Human Multiplex
R-PLEX Mouse VEGFR-1/Flt-1 Antibody Set VEGFR-1/Flt-1 \| Mouse
R-PLEX Mouse VEGFR-1/Flt-1 Assay VEGFR-1/Flt-1 \| Mouse Singleplex
U-PLEX Human Leptin 384-well Assay Leptin \| Human Singleplex
U-PLEX Custom Metabolic Group 1 (human) 384-well Assays BAFF, BDNF, β-NGF, C-Peptide, CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, FGF-21, FGF-23, FLT3L, Fractalkine, FSH, G-CSF, Ghrelin (active), Ghrelin (total), GIP (active), GIP (inactive), GIP (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, Insulin, IP-10, Leptin, Luteinizing Hormone (LH), MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-5, PP, Proinsulin, PYY (total), SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, TSLP, VEGF-A, YKL-40 \| Human Multiplex
U-PLEX Human IL-6 384-Well Assay IL-6 \| Human Singleplex
U-PLEX Human YKL-40 384-Well Assay YKL-40 \| Human Singleplex
U-PLEX Custom Biomarker Group 1 (human) 384-well Assays CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, FLT3L, Fractalkine, G-CSF, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, IP-10, I-TAC, MCP-1, MCP-2, MCP-3, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-1β, MIP-3α, MIP-3β, MIP-5, SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, TSLP, VEGF-A, YKL-40 \| Human Multiplex
U-PLEX Custom Biomarker Group 3 (human) Assays A2M, Adiponectin, ApoA1, ApoC3, CA1, Clusterin, Complement C9, Complement factor D, CRP, Cystatin C, DPPIV, Factor VII, ICAM-1, NGAL/LCN2, RBP4, SAA, Serpin A1, SHBG, sTfR-1, VCAM-1, vWF \| Human Multiplex
U-PLEX Human CRP Antibody Set CRP \| Human
U-PLEX Human VCAM-1 Antibody Set VCAM-1 \| Human
U-PLEX Human SAA Antibody Set SAA \| Human
U-PLEX Human CRP Assay CRP \| Human Singleplex
U-PLEX Human SAA Assay SAA \| Human Singleplex
U-PLEX Human VCAM-1 Assay VCAM-1 \| Human Singleplex
S-PLEX NHP IL-6 Kit IL-6 \| Non-human primate Singleplex
S-PLEX Human IL-6 Kit IL-6 \| Human Singleplex
R-PLEX Mouse CRP Antibody Set CRP \| Mouse
R-PLEX Mouse SAA Antibody Set SAA \| Mouse
Human Leptin Antibody Leptin \| Human
V-PLEX Plus Human Leptin Kit Leptin \| Human Singleplex
V-PLEX Metabolic Panel 1 Human Kit C-Peptide, GIP (active), GLP-1 (active), Glucagon, Insulin, Leptin, PP \| Human Multiplex
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A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study.

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