Upregulation of IL-17, but not of IL-9, in circulating cells of CIS and relapsing MS patients. Impact of corticosteroid therapy on the cytokine network.

Muls N, Jnaoui K, Dang HA, Wauters A, Van Snick J, Sindic CJ, van Pesch V.
Journal   J Neuroimmunol.
Species  
Analytes Measured   IL-10 , IL-12 IL-23p40 , IL-13 , IL-2 , IL-4 , IL-5 , IL-8
Matrix Tested   Cell culture supernatants
Year   2012
Volume   243
Page Numbers   73-80
Application   Cytokines and Chemokines
Abstract
The concomitant production of IL-17A and IL-9, both Th17 cytokines, has not been compared in MS patients. We show that IL-17A but not IL-9 expression by CD3(+) cells was increased during a MS relapse. Co-expression of IL-17A and IL-9 was marginal. In addition to Th1 and Th2 cytokines, IL-17A, IL-6 and IL-23p19 were down-regulated by ivMP, but Foxp3 was not, while an increase in IL-10, TGF-β1 and IL-27p28 mRNA was observed. This change in the Th17, Treg and IL-10 balance could be an additional mechanism by which corticosteroids shorten the duration of a MS relapse and promote recovery.

View Publications

Related Products

R-PLEX Rat IL-12/IL-23p40 Antibody Set
IL-12/IL-23p40 | Rat
R-PLEX Rat IL-12/IL-23p40 Assay
IL-12/IL-23p40 | Rat
Singleplex
U-PLEX CAR-T Cell Safety Combo 1 (human)
GM-CSF, IFN-γ, IL-1β, IL-6, IL-10, MCP-1, TNF-α | Human
Multiplex
U-PLEX Multiple Sclerosis Combo 1 (human)
CTACK, Fractalkine, GRO-α, IL-7, IL-12/IL-23p40, IP-10, MCP-1, MIP-1β, MIP-3α | Human
Multiplex
U-PLEX Alzheimer's Disease Combo 1 (human)
Eotaxin, IL-1α, IL-12/IL-23p40, IL-16, IL-17A, MCP-1, MDC, MIF, SDF-1α, YKL-40 | Human
Multiplex
U-PLEX Oncolysis Combo 1 (human)
CTLA-4, IFN-α2a, IFN-β, IL-1β, IL-2Rα, IL-6, IL-8, IP-10, LAG3, MIP-1α, PD1 (epitope 1), TIGIT | Human
Multiplex
U-PLEX CAR-T Cell Combo 2 (human)
GM-CSF, Granzyme A, Granzyme B, IFN-γ, IL-2, Perforin, TNF-α | Human
Multiplex
U-PLEX Custom Biomarker Group 1 (mouse) 384-well Assays
Mouse
Multiplex
U-PLEX Mouse IL-12/IL-23p40 384-Well Assay
IL-12/IL-23p40 | Mouse
Singleplex
U-PLEX Mouse IL-10 384-Well Assay
IL-10 | Mouse
Singleplex
U-PLEX Mouse IL-5 384-Well Assay
IL-5 | Mouse
Singleplex
U-PLEX Mouse IL-4 384-Well Assay
IL-4 | Mouse
Singleplex
U-PLEX Mouse IL-2 384-Well Assay
IL-2 | Mouse
Singleplex
U-PLEX Mouse IL-13 384-Well Assay
IL-13 | Mouse
Singleplex
U-PLEX NHP IL-13 384-Well Assay
IL-13 | Non-human primate
Singleplex
U-PLEX NHP IL-12/IL-23p40 384-Well Assay
IL-12/IL-23p40 | Non-human primate
Singleplex
U-PLEX NHP IL-10 384-Well Assay
IL-10 | Non-human primate
Singleplex
U-PLEX NHP IL-8 384-Well Assay
IL-8 | Non-human primate
Singleplex
U-PLEX NHP IL-5 384-Well Assay
IL-5 | Non-human primate
Singleplex
U-PLEX NHP IL-4 384-Well Assay
IL-4 | Non-human primate
Singleplex
U-PLEX NHP IL-2 384-Well Assay
IL-2 | Non-human primate
Singleplex
U-PLEX Custom Metabolic Group 1 (mouse) 384-well Assays
BAFF, BCA-1/BLC, BDNF, CD40/TNFRSF5, C-Peptide, Eotaxin, EPO, FGF-21, Ghrelin (active), Ghrelin (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, IFN-α, IFN-β, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27p28/IL-30, IL-31, IL-33, Insulin, IP-10, KC/GRO, Leptin, MCP-1, MCP-5/CCL12, MDC, MIP-1α, MIP-1β, MIP-2, MIP-3α, MMP-9 (total), PYY (total), RANTES, TARC, TNF-α, VEGF-A | Mouse
Multiplex
U-PLEX Biomarker Group 1 (NHP) 384-well Assays
CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, FLT3L, Fractalkine, G-CSF, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, IL-17F, IL-18, IL-22, IL-23, IP-10, I-TAC, MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-1β, MIP-3α, MIP-3β, MIP-5, SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, VEGF-A, YKL-40 | Non-human primate
Multiplex
U-PLEX Human IL-13 384-Well Assay
IL-13 | Human
Singleplex
U-PLEX Human IL-12/IL-23p40 384-Well Assay
IL-12/IL-23p40 | Human
Singleplex
U-PLEX Human IL-10 384-Well Assay
IL-10 | Human
Singleplex
U-PLEX Human IL-8 384-Well Assay
IL-8 | Human
Singleplex
U-PLEX Human IL-5 384-Well Assay
IL-5 | Human
Singleplex
U-PLEX Human IL-4 384-Well Assay
IL-4 | Human
Singleplex
U-PLEX Human IL-2 384-Well Assay
IL-2 | Human
Singleplex
U-PLEX Custom Metabolic Group 1 (human) 384-well Assays
BAFF, BDNF, β-NGF, C-Peptide, CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, FGF-21, FGF-23, FLT3L, Fractalkine, FSH, G-CSF, Ghrelin (active), Ghrelin (total), GIP (active), GIP (inactive), GIP (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, Insulin, IP-10, Leptin, Luteinizing Hormone (LH), MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-5, PP, Proinsulin, PYY (total), SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, TSLP, VEGF-A, YKL-40 | Human
Multiplex
U-PLEX Custom Biomarker Group 1 (human) 384-well Assays
CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, FLT3L, Fractalkine, G-CSF, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, IP-10, I-TAC, MCP-1, MCP-2, MCP-3, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-1β, MIP-3α, MIP-3β, MIP-5, SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, TSLP, VEGF-A, YKL-40 | Human
Multiplex
S-PLEX Proinflammatory Panel 1 (human) Kit
IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-17A, TNF-α | Human
Multiplex
U-PLEX Macrophage M2 Combo 1 (mouse)
IL-4, IL-10, IL-13, MDC, TARC | Mouse
Multiplex
S-PLEX Human IL-13 Kit
IL-13 | Human
Singleplex
S-PLEX NHP IL-2 Kit
IL-2 | Non-human primate
Singleplex
S-PLEX NHP IL-5 Kit
IL-5 | Non-human primate
Singleplex
S-PLEX Human IL-10 Kit
IL-10 | Human
Singleplex
S-PLEX Human IL-4 Kit
IL-4 | Human
Singleplex
S-PLEX Human IL-2 Kit
IL-2 | Human
Singleplex
S-PLEX Human IL-5 Kit
IL-5 | Human
Singleplex
U-PLEX Macrophage M2 Combo 1 (human)
Eotaxin-2, IL-4, IL-10, IL-13, M-CSF, MDC, TARC | Human
Multiplex
U-PLEX CAR-T Cell Combo 1 (human)
GM-CSF, Granzyme A, Granzyme B, IFN-γ, IL-2, TNF-α | Human
Multiplex
V-PLEX Plus Viral Panel 3 NHP Kit
IFN-γ, IL-1β, IL-5, IL-6, IL-8, IL-10 | Non-human primate
Multiplex
V-PLEX Plus Viral Panel 3 Human Kit
IFN-γ, IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-α | Human
Multiplex
V-PLEX Viral Panel 3 NHP Kit
IFN-γ, IL-1β, IL-5, IL-6, IL-8, IL-10 | Non-human primate
Multiplex
V-PLEX Viral Panel 3 Human Kit
IFN-γ, IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-α | Human
Multiplex
U-PLEX Viral Combo 1 (NHP)
G-CSF, GM-CSF, IFN-α2a, IFN-γ, IL-1β, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IP-10, MCP-1, MIP-1α, TNF-α, VEGF-A | Non-human primate
Multiplex
U-PLEX Viral Combo 1 (human)
G-CSF, GM-CSF, IFN-α2a, IFN-β, IFN-γ, IL-1β, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IP-10, MCP-1, MIP-1α, TNF-α, VEGF-A | Human
Multiplex
V-PLEX Viral Panel 2 NHP Kit
IFN-γ, IL-1β, IL-6, IL-8, IL-10 | Non-human primate
Multiplex
V-PLEX Viral Panel 2 Human Kit
IFN-γ, IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α | Human
Multiplex
V-PLEX Viral Panel 1 NHP Kit
IL-1β, IL-6, IL-8 | Non-human primate
Multiplex
V-PLEX Viral Panel 1 Human Kit
IL-1β, IL-6, IL-8, TNF-α | Human
Multiplex
V-PLEX Plus Viral Panel 2 NHP Kit
IFN-γ, IL-1β, IL-6, IL-8, IL-10 | Non-human primate
Multiplex
V-PLEX Plus Viral Panel 2 Human Kit
IFN-γ, IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α | Human
Multiplex
V-PLEX Plus Viral Panel 1 NHP Kit
IL-1β, IL-6, IL-8 | Non-human primate
Multiplex
V-PLEX Plus Viral Panel 1 Human Kit
IL-1β, IL-6, IL-8, TNF-α | Human
Multiplex
U-PLEX NHP IL-2 Assay
IL-2 | Non-human primate
Singleplex
U-PLEX NHP IL-8 Assay
IL-8 | Non-human primate
Singleplex
U-PLEX NHP IL-10 Assay
IL-10 | Non-human primate
Singleplex
U-PLEX NHP IL-5 Assay
IL-5 | Non-human primate
Singleplex
U-PLEX NHP IL-12/IL-23p40 Assay
IL-12/IL-23p40 | Non-human primate
Singleplex
U-PLEX Mouse IL-5 Assay
IL-5 | Mouse
Singleplex
U-PLEX Mouse IL-10 Assay
IL-10 | Mouse
Singleplex
U-PLEX Mouse IL-13 Assay
IL-13 | Mouse
Singleplex
U-PLEX Mouse IL-4 Assay
IL-4 | Mouse
Singleplex
U-PLEX Mouse IL-2 Assay
IL-2 | Mouse
Singleplex
U-PLEX Mouse IL-12/IL-23p40 Assay
IL-12/IL-23p40 | Mouse
Singleplex
U-PLEX NHP IL-4 Assay
IL-4 | Non-human primate
Singleplex
U-PLEX Human IL-13 Assay
IL-13 | Human
Singleplex
U-PLEX Human IL-4 Assay
IL-4 | Human
Singleplex
U-PLEX Human IL-8 Assay
IL-8 | Human
Singleplex
U-PLEX Human IL-10 Assay
IL-10 | Human
Singleplex
U-PLEX Human IL-5 Assay
IL-5 | Human
Singleplex
U-PLEX Human IL-2 Assay
IL-2 | Human
Singleplex
U-PLEX NHP IL-13 Assay
IL-13 | Non-human primate
Singleplex
U-PLEX Human IL-12/IL-23p40 Assay
IL-12/IL-23p40 | Human
Singleplex
R-PLEX Rat IL-13 Assay
IL-13 | Rat
Singleplex
R-PLEX Rat IL-10 Assay
IL-10 | Rat
Singleplex
R-PLEX Rat IL-2 Assay
IL-2 | Rat
Singleplex
R-PLEX Rat IL-4 Assay
IL-4 | Rat
Singleplex
R-PLEX Rat IL-5 Assay
IL-5 | Rat
Singleplex
U-PLEX Custom Metabolic Group 1 (mouse) Assays
Mouse
Multiplex
U-PLEX Adipokine Combo 1 (mouse)
BDNF, IL-1β, IL-6, IL-10, Insulin, Leptin, MCP-1, TNF-α | Mouse
Multiplex
U-PLEX Custom Metabolic Group 1 (human) Assays
BAFF, BDNF, β-NGF, C-Peptide, CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, FGF-21, FGF-23, FLT3L, Fractalkine, FSH, G-CSF, Ghrelin (active), Ghrelin (total), GIP (active), GIP (inactive), GIP (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, Insulin, IP-10, Leptin, Luteinizing Hormone (LH), MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-5, PP, Proinsulin, PYY (total), SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, TSLP, VEGF-A, YKL-40 | Human
Multiplex
U-PLEX Adipokine Combo 1 (human)
BDNF, β-NGF, IL-1β, IL-6, IL-8, IL-10, Insulin, Leptin, MCP-1, TNF-α | Human
Multiplex
R-PLEX Rat IL-5 Antibody Set
IL-5 | Rat
R-PLEX Rat IL-4 Antibody Set
IL-4 | Rat
R-PLEX Rat IL-10 Antibody Set
IL-10 | Rat
R-PLEX Rat IL-2 Antibody Set
IL-2 | Rat
R-PLEX Rat IL-13 Antibody Set
IL-13 | Rat
V-PLEX Plus Mouse Cytokine 19-Plex Kit
IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-17A/F, IL-27p28/IL-30, IL-33, IP-10, KC/GRO, MCP-1, MIP-1α, MIP-2, TNF-α | Mouse
Multiplex
V-PLEX Mouse Cytokine 19-Plex Kit
IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-17A/F, IL-27p28/IL-30, IL-33, IP-10, KC/GRO, MCP-1, MIP-1α, MIP-2, TNF-α | Mouse
Multiplex
U-PLEX T-Cell Combo (NHP)
GM-CSF, IFN-γ, IL-2, IL-4, IL-9, IL-10, IL-13, IL-17A, IL-17F, IL-22, MIP-3α, TNF-α | Non-human primate
Multiplex
U-PLEX T-Cell Combo (human)
GM-CSF, IFN-γ, IL-2, IL-4, IL-9, IL-10, IL-13, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, MIP-3α, TNF-α | Human
Multiplex
U-PLEX NHP IL-13 Antibody Set
IL-13 | Non-human primate
U-PLEX T-Cell Combo (mouse)
GM-CSF, IFN-γ, IL-2, IL-4, IL-9, IL-10, IL-13, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, MIP-3α, TNF-α | Mouse
Multiplex
U-PLEX Mouse IL-12/IL-23p40 Antibody Set
IL-12/IL-23p40 | Mouse
U-PLEX TH17 Combo 2 (human)
IFN-γ, IL-1β, IL-6, IL-10, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, TNF-α | Human
Multiplex
U-PLEX TH1/TH2 Combo (NHP)
IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, TNF-α | Non-human primate
Multiplex
Product Search
Browse Our Products

By Analytes
By Applications
Search
Customer Service/Orders


Scientific/Technical Support


Instrument Support


Company Headquarters