Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine.

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Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine.

Klein T, Niessen HG, Ittrich C, Mayoux E, Mueller HP, Cheetham S, Stiller D, Kassubek J, Mark M.

Journal		Diabetes Obes Metab.
Species
Analytes Measured		GLP-1 , Insulin , Leptin
Matrix Tested		Plasma

Year		2012
Volume
Page Numbers
Application		Metabolic

Abstract

The effects of linagliptin on fat content in diet-induced obese rats were compared with those of the appetite suppressant sibutramine. Female Wistar rats fed a high-fat diet (HFD) for 3 months received vehicle, linagliptin (10 mg/kg) or sibutramine (5 mg/kg) treatment orally, once daily for 6 additional weeks, while continuing the HFD. Magnetic resonance spectroscopy analysis of fat content was performed at baseline and at the end of the 6-week treatment period. Linagliptin treatment profoundly reduced hepatic fat compared with vehicle, with an effect comparable to that of sibutramine. The vehicle-corrected mean change (95% CI) from baseline in hepatic fat and intramyocellular lipid was -59.0% (-104.3%, -13.6%; p = 0.015) and -62.1% (-131.6%, 7.4%; p = 0.073), respectively, for linagliptin compared with -54.3% (-101.5%, -7.1%; p = 0.027) and -72.4% (-142.4%, -2.4%; p = 0.044), respectively, for sibutramine.

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V-PLEX Custom Human Biomarkers 1 C-Peptide, CRP, Eotaxin, Eotaxin-3, FGF (basic), GIP (active), GLP-1 (active), Glucagon, GM-CSF, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, Insulin, IP-10, Leptin, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, PP, SAA, TARC, Tie-2, TNF-α, TNF-β, TSLP, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Custom NHP Biomarkers 1 C-Peptide, Eotaxin, Eotaxin-3, GIP (active), GLP-1 (active), Glucagon, GM-CSF, IFN-γ, IL-1β, IL-2, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-15, IL-16, IL-17A, Insulin, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PP, TARC, TNF-β, VEGF-A \| Non-human primate Multiplex
U-PLEX Custom Metabolic Group 1 (ms) 384-well Assays BAFF, BCA-1/BLC, BDNF, CD40/TNFRSF5, C-Peptide, Eotaxin, EPO, FGF-21, Ghrelin (active), Ghrelin (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, IFN-α, IFN-β, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27p28/IL-30, IL-31, IL-33, Insulin, IP-10, KC/GRO, Leptin, MCP-1, MCP-5/CCL12, MDC, MIP-1α, MIP-1β, MIP-2, MIP-3α, MMP-9 (total), PYY (total), RANTES, TARC, TNF-α, VEGF-A \| Mouse Multiplex
U-PLEX Custom Metabolic Group 1 (rat) 384-well Assays BDNF, C-Peptide, FGF-21, Ghrelin (active), Ghrelin (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, Insulin, Leptin, PYY (total) \| Rat Multiplex
U-PLEX Mouse GLP-1 (total) 384-Well Assay GLP-1 (total) \| Mouse Singleplex
U-PLEX Mouse Insulin 384-Well Assay Insulin \| Mouse Singleplex
U-PLEX Mouse Leptin 384-Well Assay Leptin \| Mouse Singleplex
U-PLEX Rat GLP-1 (total) 384-Well Assay GLP-1 (total) \| Rat Singleplex
U-PLEX Rat Insulin 384-Well Assay Insulin \| Rat Singleplex
U-PLEX Rat Leptin 384-Well Assay Leptin \| Rat Singleplex
U-PLEX Custom Metabolic Group 1 (human) 384-well Assays BAFF, BDNF, β-NGF, C-Peptide, CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, FGF-21, FGF-23, FLT3L, Fractalkine, FSH, G-CSF, Ghrelin (active), Ghrelin (total), GIP (active), GIP (inactive), GIP (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, Insulin, IP-10, Leptin, Luteinizing Hormone (LH), MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-5, PP, Proinsulin, PYY (total), SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, TSLP, VEGF-A, YKL-40 \| Human Multiplex
U-PLEX Human GLP-1 (total) 384-well Assay GLP-1 (total) \| Human Singleplex
U-PLEX Human Insulin 384-well Assay Insulin \| Human Singleplex
U-PLEX Human Leptin 384-well Assay Leptin \| Human Singleplex
Human Insulin Antibody Insulin \| Human, Non-human primate, Canine
Human Leptin Antibody Leptin \| Human
V-PLEX Human Insulin Kit Insulin \| Human, Non-human primate, Canine Singleplex
V-PLEX Human Leptin Kit Leptin \| Human Singleplex
V-PLEX Metabolic Panel 1 Canine Kit GIP (active), GLP-1 (active), Glucagon, Insulin \| Canine Multiplex
V-PLEX Metabolic Panel 1 Human Kit C-Peptide, GIP (active), GLP-1 (active), Glucagon, Insulin, Leptin, PP \| Human Multiplex
V-PLEX Metabolic Panel 1 NHP Kit C-Peptide, GIP (active), GLP-1 (active), Glucagon, Insulin, PP \| Non-human primate Multiplex
V-PLEX Plus Human Insulin Kit Insulin \| Human, Non-human primate, Canine Singleplex
V-PLEX Plus Human Leptin Kit Leptin \| Human Singleplex
V-PLEX Plus Metabolic Panel 1 Canine Kit GIP (active), GLP-1 (active), Glucagon, Insulin \| Canine Multiplex
V-PLEX Plus Metabolic Panel 1 Human Kit C-Peptide, GIP (active), GLP-1 (active), Glucagon, Insulin, Leptin, PP \| Human Multiplex
V-PLEX Plus Metabolic Panel 1 NHP Kit C-Peptide, GIP (active), GLP-1 (active), Glucagon, Insulin, PP \| Non-human primate Multiplex
U-PLEX Human GLP-1 (total) Assay GLP-1 (total) \| Human Singleplex
U-PLEX Human Insulin Assay Insulin \| Human Singleplex
U-PLEX Human Leptin Assay Leptin \| Human Singleplex
U-PLEX Mouse GLP-1 (total) Assay GLP-1 (total) \| Mouse Singleplex
U-PLEX Mouse Insulin Assay Insulin \| Mouse Singleplex
U-PLEX Mouse Leptin Assay Leptin \| Mouse Singleplex
U-PLEX Rat GLP-1 (total) Assay GLP-1 (total) \| Rat Singleplex
U-PLEX Rat Insulin Assay Insulin \| Rat Singleplex
U-PLEX Rat Leptin Assay Leptin \| Rat Singleplex
U-PLEX Mouse/Rat Leptin Antibody Set Leptin \| Mouse, Rat
U-PLEX Mouse/Rat Insulin Antibody Set Insulin \| Mouse, Rat
U-PLEX GLP-1 (total) Antibody Set (5 Plate Size) GLP-1 (total) \| Human, Mouse, Rat
U-PLEX Human Leptin Antibody Set Leptin \| Human
U-PLEX Human Insulin Antibody Set Insulin \| Human
V-PLEX GLP-1 (total) Kit GLP-1 (total) \| Human, Mouse, Non-human primate, Rat, Canine Singleplex
V-PLEX Plus GLP-1 (total) Kit GLP-1 (total) \| Human, Mouse, Non-human primate, Rat, Canine Singleplex
GLP-1 (total) Control Pack GLP-1 (total) \| Human, Mouse, Non-human primate, Rat, Canine
Mouse Metabolic Kit Insulin, Leptin \| Mouse Multiplex
Mouse/Rat Insulin Kit Insulin \| Mouse, Rat Singleplex
Human Insulin Kit Insulin \| Human Singleplex
GLP-1 (total) Antibody GLP-1 (total) \| Human
V-PLEX Custom Canine Biomarkers GIP (active), GLP-1 (active), Glucagon, Insulin \| Canine Multiplex

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Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine.

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