Blood protein profiles of infants born before 28th week differ by pregnancy complication.

McElrath, T.F., Fichorova, R.N., Allred, E.N., Hecht, J.L., Ismail, M.A., Yuan, H., Leviton, A; ELGAN Study Investigators.
Journal   Am J Obstet Gynecol.
Species  
Analytes Measured   CRP , E-Selectin , I-TAC , ICAM-1 , ICAM-3 , IGFBP-1 , IL-6 , IL-6R , IL-8 , MCP-1 , MCP-4 , MMP-1 , MMP-9 , MPO , RANTES , SAA , TNF-RI , TNF-RII , VCAM-1 , Flt-1 VEGFR1
Matrix Tested   Dried blood spots
Year   2011
Volume   204
Page Numbers  
Application   Cytokines and Chemokines
Abstract

OBJECTIVE: Disorders that lead to preterm delivery influence the fetal inflammatory response.

STUDY DESIGN: We calculated odds ratios of elevated concentrations of 25 blood proteins on the first postnatal day in 798 infants born before the 28th week and classified by the pregnancy disorder that lead to preterm delivery.

RESULTS: Concentrations of cytokines (IL-1β, IL-6, TNFα), cytokine receptors (IL-6R, TNF-R1, TNF-R2), systemic inflammatory proteins (CRP, SAA, MPO), chemokines (IL-8, MCP-1, MCP-4, MIP-1β, RANTES, I-TAC), adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin), and metalloproteinases (MMP-1, MMP-9) were elevated in children delivered after preterm labor, membrane rupture, abruption, and cervical insufficiency, whereas such a pattern was not seen after preeclampsia or fetal indication/growth restriction. Inflammatory profiles were also associated with maternal vaginitis.

CONCLUSION: The patterns of blood proteins in the newborn support the division of pregnancy disorders that lead to preterm delivery into those associated, and those not associated, with inflammation.

View Publications

Related Products

R-PLEX Rat ICAM-1 Assay
ICAM-1 | Rat
Singleplex
NEW
R-PLEX Rat ICAM-1 Antibody Set
ICAM-1 | Rat
NEW
U-PLEX Long COVID Combo 1 (human)
IFN-β, IFN-γ, IL-6, Pentraxin 3 | Human
Multiplex
V-PLEX Human MCP-1 Gen. B Kit
MCP-1 | Human
Singleplex
V-PLEX Chemokine Panel 1 (human) Gen. B Kit
Eotaxin, Eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC | Human
Multiplex
Human MCP-4 Antibody
MCP-4 | Human
Human MCP-1 Antibody
MCP-1 | Human
V-PLEX NHP MCP-1 Gen. B Kit
MCP-1 | Non-human primate
Singleplex
V-PLEX Plus NHP MCP-1 Gen. B Kit
MCP-1 | Non-human primate
Singleplex
V-PLEX Plus Chemokine Panel 1 (human) Gen. B Kit
Eotaxin, Eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC | Human
Multiplex
V-PLEX NHP MCP-4 Gen. B Kit
MCP-4 | Non-human primate
Singleplex
V-PLEX Plus NHP MCP-4 Gen. B Kit
MCP-4 | Non-human primate
Singleplex
V-PLEX Chemokine Panel 1 (NHP) Gen. B Kit
Eotaxin, Eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC | Non-human primate
Multiplex
V-PLEX Plus Chemokine Panel 1 (NHP) Gen. B Kit
Eotaxin, Eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC | Non-human primate
Multiplex
V-PLEX Human MCP-4 Gen. B Kit
MCP-4 | Human
Singleplex
V-PLEX Plus Human MCP-1 Gen. B Kit
MCP-1 | Human
Singleplex
V-PLEX Plus Human MCP-4 Gen. B Kit
MCP-4 | Human
Singleplex
Chemokine Panel 1 (human) Gen. B Control Pack
Eotaxin, Eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC | Human
R-PLEX Mouse E-selectin Antibody Set
E-Selectin | Mouse
R-PLEX Mouse E-selectin Assay
E-Selectin | Mouse
Singleplex
R-PLEX Mouse I-TAC Antibody Set
I-TAC | Mouse
R-PLEX Mouse I-TAC Assay
I-TAC | Mouse
Singleplex
R-PLEX Human MMP-9 (active) Antibody Set
MMP-9 (active) | Human
R-PLEX Human MMP-9 (active) Assay
MMP-9 (active) | Human
Singleplex
U-PLEX CAR-T Cell Safety Combo 1 (human)
GM-CSF, IFN-γ, IL-1β, IL-6, IL-10, MCP-1, TNF-α | Human
Multiplex
R-PLEX Mouse ICAM-1 Antibody Set
ICAM-1 | Mouse
R-PLEX Mouse VCAM-1 Antibody Set
VCAM-1 | Mouse
R-PLEX Mouse VCAM-1 Assay
VCAM-1 | Mouse
Singleplex
R-PLEX Mouse ICAM-1 Assay
ICAM-1 | Mouse
Singleplex
U-PLEX TBI Combo 1 (human)
CD40L (soluble), Fractalkine, IFN-γ, IL-1β, IL-6, IL-18, MCP-1, RANKL/TNFSF11, TNF-α, VEGF-D | Human
Multiplex
U-PLEX Multiple Sclerosis Combo 1 (human)
CTACK, Fractalkine, GRO-α, IL-7, IL-12/IL-23p40, IP-10, MCP-1, MIP-1β, MIP-3α | Human
Multiplex
U-PLEX Alzheimer's Disease Combo 1 (human)
Eotaxin, IL-1α, IL-12/IL-23p40, IL-16, IL-17A, MCP-1, MDC, MIF, SDF-1α, YKL-40 | Human
Multiplex
U-PLEX Human TNF-RII 384-well Assay
TNF-RII | Human
Singleplex
U-PLEX Human TNF-RI 384-well Assay
TNF-RI | Human
Singleplex
U-PLEX Human RANTES 384-well Assay
RANTES | Human
Singleplex
U-PLEX Human RANTES Antibody Set
RANTES | Human
U-PLEX Human MMP-1 Antibody Set
MMP-1 | Human
U-PLEX Human TNF-RII Antibody Set
TNF-RII | Human
U-PLEX Human TNF-RI Antibody Set
TNF-RI | Human
U-PLEX Human VEGFR-1/Flt-1 Antibody Set
VEGFR-1/Flt-1 | Human
U-PLEX Human E-Selectin 384-well Assay
E-Selectin | Human
Singleplex
U-PLEX Human MMP-1 384-well Assay
MMP-1 | Human
Singleplex
U-PLEX Human VEGFR-1/Flt-1 384-well Assay
VEGFR-1/Flt-1 | Human
Singleplex
U-PLEX Metastasis Combo 1 (human)
E-Selectin, MMP-1, MMP-2, MMP-7, MMP-9 (total), P-Selectin, VEGFR-1/Flt-1 | Human
Multiplex
U-PLEX Human E-Selectin Antibody Set
E-Selectin | Human
U-PLEX Human RANTES Assay
RANTES | Human
Singleplex
U-PLEX Human TNF-RII Assay
TNF-RII | Human
Singleplex
U-PLEX Human TNF-RI Assay
TNF-RI | Human
Singleplex
U-PLEX Human VEGFR-1/Flt-1 Assay
VEGFR-1/Flt-1 | Human
Singleplex
U-PLEX Human MMP-1 Assay
MMP-1 | Human
Singleplex
U-PLEX Human E-Selectin Assay
E-Selectin | Human
Singleplex
U-PLEX Oncolysis Combo 1 (human)
CTLA-4, IFN-α2a, IFN-β, IL-1β, IL-2Rα, IL-6, IL-8, IP-10, LAG3, MIP-1α, PD1 (epitope 1), TIGIT | Human
Multiplex
U-PLEX Macrophage M1 Combo 1 (mouse)
IL-1β, IL-6, IL-12p70, IL-15, IL-23, IP-10, MCP-1, MIP-1α, TNF-α | Mouse
Multiplex
U-PLEX Custom Biomarker Group 1 (mouse) 384-well Assays
Mouse
Multiplex
U-PLEX Mouse IL-6 384-Well Assay
IL-6 | Mouse
Singleplex
U-PLEX Mouse MCP-1 384-Well Assay
MCP-1 | Mouse
Singleplex
U-PLEX Mouse TNF-RI 384-Well Assay
TNF-RI | Mouse
Singleplex
U-PLEX Mouse RANTES 384-Well Assay
RANTES | Mouse
Singleplex
U-PLEX NHP IL-8 384-Well Assay
IL-8 | Non-human primate
Singleplex
U-PLEX NHP IL-6 384-Well Assay
IL-6 | Non-human primate
Singleplex
U-PLEX NHP MCP-1 384-Well Assay
MCP-1 | Non-human primate
Singleplex
U-PLEX NHP I-TAC 384-Well Assay
I-TAC | Non-human primate
Singleplex
U-PLEX Custom Metabolic Group 1 (mouse) 384-well Assays
BAFF, BCA-1/BLC, BDNF, CD40/TNFRSF5, C-Peptide, Eotaxin, EPO, FGF-21, Ghrelin (active), Ghrelin (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, IFN-α, IFN-β, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27p28/IL-30, IL-31, IL-33, Insulin, IP-10, KC/GRO, Leptin, MCP-1, MCP-5/CCL12, MDC, MIP-1α, MIP-1β, MIP-2, MIP-3α, MMP-9 (total), PYY (total), RANTES, TARC, TNF-α, VEGF-A | Mouse
Multiplex
U-PLEX Human CRP 384-Well Assay
CRP | Human
Singleplex
U-PLEX Human VCAM-1 384-Well Assay
VCAM-1 | Human
Singleplex
U-PLEX Human ICAM-1 384-Well Assay
ICAM-1 | Human
Singleplex
U-PLEX Human SAA 384-Well Assay
SAA | Human
Singleplex
U-PLEX Biomarker Group 1 (NHP) 384-well Assays
CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, FLT3L, Fractalkine, G-CSF, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, IL-17F, IL-18, IL-22, IL-23, IP-10, I-TAC, MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-1β, MIP-3α, MIP-3β, MIP-5, SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, VEGF-A, YKL-40 | Non-human primate
Multiplex
U-PLEX Custom Biomarker Group 3 (human) 384-well Assays
Human
Multiplex
R-PLEX Mouse VEGFR-1/Flt-1 Antibody Set
VEGFR-1/Flt-1 | Mouse
R-PLEX Mouse VEGFR-1/Flt-1 Assay
VEGFR-1/Flt-1 | Mouse
Singleplex
U-PLEX Human IL-8 384-Well Assay
IL-8 | Human
Singleplex
U-PLEX Human IL-6 384-Well Assay
IL-6 | Human
Singleplex
U-PLEX Human MCP-1 384-Well Assay
MCP-1 | Human
Singleplex
U-PLEX Human I-TAC 384-Well Assay
I-TAC | Human
Singleplex
U-PLEX Custom Metabolic Group 1 (human) 384-well Assays
BAFF, BDNF, β-NGF, C-Peptide, CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, FGF-21, FGF-23, FLT3L, Fractalkine, FSH, G-CSF, Ghrelin (active), Ghrelin (total), GIP (active), GIP (inactive), GIP (total), GLP-1 (active), GLP-1 (inactive), GLP-1 (total), Glucagon, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, Insulin, IP-10, Leptin, Luteinizing Hormone (LH), MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-5, PP, Proinsulin, PYY (total), SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, TSLP, VEGF-A, YKL-40 | Human
Multiplex
U-PLEX Custom Biomarker Group 1 (human) 384-well Assays
CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, EPO, FLT3L, Fractalkine, G-CSF, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-β, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-2Rα, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, IL-17F, IL-18, IL-21, IL-22, IL-23, IL-27, IL-29/IFN-λ1, IL-31, IL-33, IP-10, I-TAC, MCP-1, MCP-2, MCP-3, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-1β, MIP-3α, MIP-3β, MIP-5, SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, TSLP, VEGF-A, YKL-40 | Human
Multiplex
Human MCP-4 Antibody
MCP-4 | Human
U-PLEX Custom Biomarker Group 3 (human) Assays
Human
Multiplex
U-PLEX Human CRP Antibody Set
CRP | Human
U-PLEX Human ICAM-1 Antibody Set
ICAM-1 | Human
U-PLEX Human SAA Antibody Set
SAA | Human
U-PLEX Human VCAM-1 Antibody Set
VCAM-1 | Human
U-PLEX Metabolic Combo 2 (human)
Adiponectin, ApoA1, ApoC3, Clusterin, CRP, DPPIV, NGAL/LCN2, RBP4, SHBG, sTfR-1 | Human
Multiplex
U-PLEX Vascular Injury Combo 1 (human)
CRP, Factor VII, ICAM-1, SAA, VCAM-1 | Human
Multiplex
U-PLEX Inflammation Combo 1 (human)
Complement C9, Complement factor D, CRP, ICAM-1, NGAL/LCN2, SAA, VCAM-1 | Human
Multiplex
U-PLEX Human VCAM-1 Assay
VCAM-1 | Human
Singleplex
U-PLEX Human SAA Assay
SAA | Human
Singleplex
U-PLEX Human CRP Assay
CRP | Human
Singleplex
U-PLEX Human ICAM-1 Assay
ICAM-1 | Human
Singleplex
S-PLEX Proinflammatory Panel 1 (human) Kit
IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-17A, TNF-α | Human
Multiplex
S-PLEX NHP IL-6 Kit
IL-6 | Non-human primate
Singleplex
S-PLEX Human IL-6 Kit
IL-6 | Human
Singleplex
R-PLEX Human IGFBP-1 Antibody Set
IGFBP-1 | Human
R-PLEX Mouse CRP Antibody Set
CRP | Mouse
R-PLEX Mouse SAA Antibody Set
SAA | Mouse
U-PLEX Macrophage M1 Combo 1 (human)
IL-1β, IL-6, IL-12p70, IL-18, IL-23, IP-10, MCP-1, MIP-1α, TNF-α | Human
Multiplex
V-PLEX Viral Panel 3 NHP Kit
IFN-γ, IL-1β, IL-5, IL-6, IL-8, IL-10 | Non-human primate
Multiplex
V-PLEX Viral Panel 3 Human Kit
IFN-γ, IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-α | Human
Multiplex
V-PLEX Plus Viral Panel 3 NHP Kit
IFN-γ, IL-1β, IL-5, IL-6, IL-8, IL-10 | Non-human primate
Multiplex
Product Search
Browse Our Products

By Analytes
By Applications
Search
Customer Service/Orders


Scientific/Technical Support


Instrument Support


Company Headquarters