Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Nguyen, H.P., Bjorkqvist, M., Bode, F.J., Stephan, M., von Horsten, S.
Journal   PLoS Curr.
Species  
Analytes Measured   IL-13
Matrix Tested   Serum
Year   2010
Volume   2
Page Numbers  
Application   Cytokines and Chemokines
Abstract
To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

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