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Home > References > 2008 > IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma.

IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma.

Calvo, K.R., Dabir, B., Kovach, A., Devor, C., Bandle, R., Bond, A., Shih, J.H., Jaffe, E.S.
Journal   Blood
Species  
Analytes Measured   IL-10 , IL-12 p70 , IL-13 , IL-2 , IL-4 , IL-5 , IL-8
Matrix Tested   Lymph node cell lysates from follicular lymphoma patients
Year   2008
Volume   112
Page Numbers   3818-26
Application   Cytokines and Chemokines
Abstract
Follicular lymphoma (FL) is characterized by constitutive expression of Bcl-2 as a consequence of t(14;18). Evidence suggests factors in the lymph node microenvironment, related to intratumoral T cells, macrophages, and dendritic cells, play a role in the disease process. We generated proteomic cytokine profiles of FL (N = 50) and follicular hyperplasia (FH; N = 23). A total of 10 cytokines were assayed using ultrasensitive multiplex enzyme-linked immunosorbent assays: IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-13, IL-12p70, tumor necrosis factor-alpha, and interferon-gamma. Each cytokine showed overall lower protein concentrations in FL, with the exception of IL-4, which was nearly 5 times higher in FL than FH (P = .005). Using reverse-phase protein microarrays (RPMAs), we evaluated the activation state of several intracellular signaling proteins downstream of cytokine receptors. Basal Erk phosphorylation was approximately 4 times greater in FL than FH (P < .001), with similar findings for Mek; Stat-6 showed weak basal phosphorylation that was approximately twice as high in FL than in FH (P = .012). In conclusion, the FL microenvironment contains increased levels of IL-4, with prominent tumor basal phosphorylation of Erk. These findings suggest IL-4, Erk, and possibly Stat-6 may play a role in the biology of FL and may serve as targets for future therapies.

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Multiplex
V-PLEX Plus Viral Panel 1 Human Kit
IL-1β, IL-6, IL-8, TNF-α | Human
Multiplex
U-PLEX NHP IL-12p70 Assay
IL-12p70 | Non-human primate
Singleplex
U-PLEX NHP IL-4 Assay
IL-4 | Non-human primate
Singleplex
U-PLEX Human IL-5 Assay
IL-5 | Human
Singleplex
U-PLEX Human IL-4 Assay
IL-4 | Human
Singleplex
U-PLEX Human IL-2 Assay
IL-2 | Human
Singleplex
U-PLEX Human IL-12p70 Assay
IL-12p70 | Human
Singleplex
U-PLEX Human IL-10 Assay
IL-10 | Human
Singleplex
U-PLEX Human IL-8 Assay
IL-8 | Human
Singleplex
U-PLEX Human IL-13 Assay
IL-13 | Human
Singleplex
U-PLEX NHP IL-2 Assay
IL-2 | Non-human primate
Singleplex
U-PLEX NHP IL-10 Assay
IL-10 | Non-human primate
Singleplex
U-PLEX NHP IL-8 Assay
IL-8 | Non-human primate
Singleplex
U-PLEX NHP IL-5 Assay
IL-5 | Non-human primate
Singleplex
U-PLEX Mouse IL-13 Assay
IL-13 | Mouse
Singleplex
U-PLEX Mouse IL-12p70 Assay
IL-12p70 | Mouse
Singleplex
U-PLEX Mouse IL-10 Assay
IL-10 | Mouse
Singleplex
U-PLEX Mouse IL-5 Assay
IL-5 | Mouse
Singleplex
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