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The
V-PLEX platform offers analytically validated singleplex and multiplex assay kits. Developed under rigorous design control, V-PLEX kits provide accurate and reproducible results with consistency from lot to lot. The V-PLEX Neuroinflammation Panel 1 (human) Kit includes 37 biomarkers that are that are associated with neuroinflammatory responses (Table 1). The assays can be used for quantitative measurements in the sample types listed in the “Specifications” tab below and offer detection limits (LLODs and LLOQs) in the sub- to low pg/mL range.
| Analyte |
LLOD |
LLOQ |
ULOQ |
Dynamic Range |
Unit |
| CRP |
1.33 |
27.6 |
49,600 |
1.33 - 49,600 |
pg/mL |
| Eotaxin |
0.20 |
2.14 |
910 |
0.20 - 910 |
pg/mL |
| Eotaxin-3 |
1.44 |
11.1 |
11,100 |
1.44 - 11,100 |
pg/mL |
| FGF (basic) |
0.09 |
2.6 |
1,780 |
0.09 - 1,780 |
pg/mL |
| ICAM-1 |
1.94 |
15 |
32,700 |
1.94 - 32,700 |
pg/mL |
| IFN-γ |
0.37 |
1.76 |
938 |
0.37 - 938 |
pg/mL |
| IL-1α |
0.09 |
2.85 |
278 |
0.09 - 278 |
pg/mL |
| IL-1β |
0.05 |
0.646 |
375 |
0.05 - 375 |
pg/mL |
| IL-2 |
0.09 |
0.89 |
938 |
0.09 - 938 |
pg/mL |
| IL-4 |
0.02 |
0.218 |
158 |
0.02 - 158 |
pg/mL |
| IL-5 |
0.14 |
4.41 |
562 |
0.14 - 562 |
pg/mL |
| IL-6 |
0.06 |
0.633 |
488 |
0.06 - 488 |
pg/mL |
| IL-7 |
0.12 |
0.851 |
563 |
0.12 - 563 |
pg/mL |
| IL-8 |
0.07 |
0.591 |
375 |
0.07 - 375 |
pg/mL |
| IL-10 |
0.04 |
0.298 |
233 |
0.04 - 233 |
pg/mL |
| IL-12/IL-23p40 |
0.33 |
1.32 |
2,250 |
0.33 - 2,250 |
pg/mL |
| IL-13 |
0.24 |
4.21 |
353 |
0.24 - 353 |
pg/mL |
| IL-15 |
0.15 |
0.774 |
525 |
0.15 - 525 |
pg/mL |
| IL-16 |
2.83 |
19.1 |
1,870 |
2.83 - 1,870 |
pg/mL |
| IL-17A |
0.31 |
3.19 |
3,650 |
0.31 - 3,650 |
pg/mL |
| IP-10 |
0.12 |
1.29 |
1,240 |
0.12 - 1,240 |
pg/mL |
| MCP-1 |
0.16 |
1.45 |
247 |
0.16 - 247 |
pg/mL |
| MCP-4 |
0.05 |
0.518 |
234 |
0.05 - 0.518 |
pg/mL |
| MDC |
1.00 |
6.43 |
2,930 |
1.00 - 2,930 |
pg/mL |
| MIP-1α |
0.05 |
0.357 |
403 |
0.05 - 403 |
pg/mL |
| MIP-1β |
0.09 |
1.20 |
390 |
0.09 - 390 |
pg/mL |
| PlGF |
0.21 |
1.5 |
800 |
0.21 - 800 |
pg/mL |
| SAA |
10.9 |
54 |
13,8000 |
10.9 - 138,000 |
pg/mL |
| TARC |
0.11 |
2.14 |
481 |
0.11 - 481 |
pg/mL |
| Tie-2 |
31.3 |
396 |
63,400 |
31.3 - 63,400 |
pg/mL |
| TNF-α |
0.04 |
0.69 |
248 |
0.04 - 248 |
pg/mL |
| TNF-β |
0.08 |
0.465 |
458 |
0.08 - 458 |
pg/mL |
| VCAM-1 |
6 |
37.6 |
32,000 |
6.00 - 32,000 |
pg/mL |
| VEGF-A |
1.12 |
7.7 |
562 |
1.12 - 562 |
pg/mL |
| VEGF-C |
9.91 |
146 |
17,500 |
9.91 - 17,500 |
pg/mL |
| VEGF-D |
4.36 |
67.1 |
18,800 |
4.36 - 18,800 |
pg/mL |
| VEGFR-1/Flt-1 |
0.9 |
10 |
6,410 |
0.90 - 6,410 |
pg/mL |
-
-
Specifications
-
Kit Contents
-
Documentation
-
References
|
Application(s)
|
|
Neuroinflammation
,
Cytokines & Chemokines
,
Immunology/Inflammation
|
|
|
Analyte(s)
|
|
CRP, Eotaxin, Eotaxin-3, FGF (basic), ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1
|
|
|
Species
|
|
Human
|
|
|
Instrument(s)
|
|
SECTOR Imager 2400
,
MESO SECTOR S 600MM
,
SECTOR Imager 6000
,
MESO QuickPlex SQ 120MM
,
MESO QuickPlex SQ 120
,
MESO SECTOR S 600
|
|
|
Plate Type
|
|
96-well
|
|
|
Sample Type
|
|
CSF
|
|
|
Usage Statement
|
|
For Research Use Only. Not for use in diagnostic procedures.
|
|
|
Storage Statement(s)
|
|
Please refer to the product insert for the storage conditions of individual kit components.
|
|
|
Storage Condition
|
|
Multi-Component
|
|
|
Schedule B Code
|
|
3822.19.0000
|
|
|
Product Description
|
Storage
|
Quantity per Kit
|
|
Proinflammatory Panel1 (human) Kit V-PLEX
|
Multi-Component
|
1 each
(1 plate size)
|
|
|
|
Cytokine Panel 1 Human Kit V-PLEX
|
Multi-Component
|
1 each
(1 plate size)
|
|
|
|
Angiogenesis Panel 1 Human Kit V-PLEX
|
Multi-Component
|
1 each
(1 plate size)
|
|
|
|
|
Multi-Component
|
1 each
(1 plate size)
|
|
|
|
|
Multi-Component
|
1 each
(1 plate size)
|
|
|
|
Product Description
|
Storage
|
Quantity per Kit
|
|
Proinflammatory Panel1 Human Kit V-PLEX
|
Multi-Component
|
1 each
(5 plate size)
|
|
|
|
Cytokine Panel 1 Human Kit V-PLEX
|
Multi-Component
|
1 each
(5 plate size)
|
|
|
|
Angiogenesis Panel 1 Human Kit V-PLEX
|
Multi-Component
|
1 each
(5 plate size)
|
|
|
|
|
Multi-Component
|
1 each
(5 plate size)
|
|
|
|
|
Multi-Component
|
1 each
(5 plate size)
|
|
|
|
Product Description
|
Storage
|
Quantity per Kit
|
|
Proinflammatory Panel1 Human Kit V-PLEX
|
Multi-Component
|
1 each
(25 plate size)
|
|
|
|
Cytokine Panel 1 Human Kit V-PLEX
|
Multi-Component
|
1 each
(25 plate size)
|
|
|
|
Angiogenesis Panel 1 Human Kit V-PLEX
|
Multi-Component
|
1 each
(25 plate size)
|
|
|
|
|
Multi-Component
|
1 each
(25 plate size)
|
|
|
|
|
Multi-Component
|
1 each
(25 plate size)
|
|
|
|
Product Inserts
|
|
|
|
SDS
|
|
-
Blocker A
-
Diluent 10, Diluent 11, Diluent 12, Diluent 13, Diluent 15, Diluent 16 and Diluent 17
-
Diluent 2, Diluent 3, Diluent 5, Diluent 7 and Diluent 8
-
Diluent 41, Diluent 43 and Diluent 45
-
Diluent 50, Diluent 56, Diluent 61, Diluent 100, and Diluent 101
-
Diluent 57, Diluent 58, and Diluent 59
-
MSD Calibrators and Controls
-
MSD GOLD Read Buffer B
-
Phosphate Buffer (5x)
-
Read Buffer T (4x), Read Buffer S (4x) and Read Buffer S (1x)
-
Wash Buffer (20X)
|
|
Title
|
Journal
|
Year
|
|
Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke
|
|
|
|
A phase 1 study of prophylactic anakinra to mitigate ICANS in patients with large B-cell lymphoma
|
|
|
|
Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms
|
|
|
|
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations
|
|
|
|
Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection
|
|
|
|
|
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|
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