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NEW U-PLEX Angiogenesis Combo 1 (human)

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U-PLEX Combos offer popular panels of biomarkers that have been grouped together for convenient ordering. They have been tested for multiplex compatibility and are fulfilled as a kit. The U-PLEX Angiogenesis Combo 1 (human) combines 5 analytes (Table 1) that are associated with angiogenesis and tumor growth. The assays can be used for quantitative measurements of the sample type(s) listed in the "Specifications" tab below, and offer detection limits (LLODs) in the sub- to low pg/mL range. This Combo is provided on 2 plates.

Table 1. List of analytes and typical detection limits

Analyte	LLOD - ULOD	Unit
FGF (basic)	2.1 - 1,200	pg/mL
PlGF	0.19 - 1,200	pg/mL
Tie-2	2.9 - 29,000	pg/mL
VEGF-A	2.0 - 4,900	pg/mL
VEGF-D	0.30 - 1,500	pg/mL

Specifications
Kit Contents
Documentation
References

Application(s)		Cardiovascular
Analyte(s)		FGF (basic), PlGF, Tie-2, VEGF-A, VEGF-D
Species		Human
Plate Type		96-well
U-PLEX Group Compatibility		Immuno-Oncology Group 1
Instrument(s)		MESO SECTOR S 600MM , MESO QuickPlex SQ 120MM , MESO QuickPlex Q 60MM , MESO SECTOR S 600 , MESO QuickPlex SQ 120 , SECTOR Imager 6000 , SECTOR Imager 2400
Sample Type		Plasma, Serum
Usage Statement		For Research Use Only. Not for use in diagnostic procedures.
Storage Statement(s)		Please refer to the product insert for the storage conditions of individual kit components.
Storage Condition		Multi-Component
Schedule B Code		3822.19.0000

Kit Contents for Catalog No. K15339K-1

Product Description

Storage

Quantity per Kit

Human Angiogenesis Combo 1, Box 1 of 2 (1 PL)

Multi-Component

1 each
(1 each)

U-PLEX Linker Set, 4-Assay (300 µL)	2-8 °C	1 each
U-PLEX Human VEGF-A Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)
U-PLEX Human PlGF Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)
U-PLEX Human VEGF-D Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)
U-PLEX Human FGF (basic) Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)
Calibrator 1	2-8 °C	1 vial (1 vial)
Calibrator 21	2-8 °C	1 vial (1 vial)
U-PLEX 4-Assay, 96-Well SECTOR Plate	2-8 °C	1 each (1 plate)
U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)
Diluent 3	≤-10 °C	1 bottle (8 mL)
Diluent 58, 10 mL	≤-10 °C	1 bottle (10 mL)
MSD GOLD Read Buffer B	RT	1 bottle (18 mL)

Human Angiogenesis Combo 1, Box 2 of 2 (1 PL)

Multi-Component

1 each
(1 each)

U-PLEX Linker Set, 1-Assay (300 μL)	2-8 °C	1 each (1 vial)
U-PLEX Human Tie-2 Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)
Calibrator 22	2-8 °C	1 vial (1 vial)
U-PLEX 2-Assay, 96-Well SECTOR Plate	2-8 °C	1 each (1 plate)
Diluent 100	2-8 °C	1 bottle (50 mL)
U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)
Diluent 3	≤-10 °C	1 bottle (8 mL)
Diluent 58, 10 mL	≤-10 °C	1 bottle (10 mL)
MSD GOLD Read Buffer B	RT	1 bottle (18 mL)

Kit Contents for Catalog No. K15339K-2

Product Description

Storage

Quantity per Kit

Human Angiogenesis Combo 1, Box 1 of 2 (5 PL)

Multi-Component

1 each
(5 each)

U-PLEX Linker Set, 4-Assay (1.8 mL)	2-8 °C	1 each
U-PLEX Human VEGF-A Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)
U-PLEX Human PlGF Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)
U-PLEX Human VEGF-D Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)
U-PLEX Human FGF (basic) Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)
Calibrator 1	2-8 °C	5 vial (1 vial)
Calibrator 21	2-8 °C	5 vial (1 vial)
U-PLEX 4-Assay, 96-Well SECTOR Plate	2-8 °C	5 each (1 plate)
U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)
Diluent 3	≤-10 °C	1 bottle (40 mL)
Diluent 58	≤-10 °C	1 bottle (50 mL)
MSD GOLD Read Buffer B	RT	1 bottle (90 mL)

Human Angiogenesis Combo 1, Box 2 of 2 (5 PL)

Multi-Component

1 each
(5 each)

U-PLEX Linker Set, 1-Assay (1.8 mL)	2-8 °C	1 each (1 vial)
U-PLEX Human Tie-2 Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)
Calibrator 22	2-8 °C	5 vial (1 vial)
U-PLEX 2-Assay, 96-Well SECTOR Plate	2-8 °C	5 each (1 plate)
Diluent 100	2-8 °C	1 bottle (200 mL)
U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)
Diluent 3	≤-10 °C	1 bottle (40 mL)
Diluent 58	≤-10 °C	1 bottle (50 mL)
MSD GOLD Read Buffer B	RT	1 bottle (90 mL)

Kit Contents for Catalog No. K15339K-4

Product Description

Storage

Quantity per Kit

Human Angiogenesis Combo 1, Box 1 of 2 (25 PL)

Multi-Component

1 each
(25 each)

U-PLEX Linker Set, 4-Assay (1.8 mL)	2-8 °C	5 each
U-PLEX Human VEGF-A Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)
U-PLEX Human PlGF Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)
U-PLEX Human VEGF-D Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)
U-PLEX Human FGF (basic) Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)
Calibrator 1	2-8 °C	25 vial (1 vial)
Calibrator 21	2-8 °C	25 vial (1 vial)
U-PLEX 4-Assay, 96-Well SECTOR Plate	2-8 °C	25 each (1 plate)
U-PLEX Stop Solution	2-8 °C	5 bottle (40 mL)
Diluent 3	≤-10 °C	5 bottle (40 mL)
Diluent 58	≤-10 °C	5 bottle (50 mL)
MSD GOLD Read Buffer B	RT	5 bottle (90 mL)

Human Angiogenesis Combo 1, Box 2 of 2 (25 PL)

Multi-Component

1 each
(25 each)

U-PLEX Linker Set, 1-Assay (1.8 mL)	2-8 °C	5 each (1 vial)
U-PLEX Human Tie-2 Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)
Calibrator 22	2-8 °C	25 vial (1 vial)
U-PLEX 2-Assay, 96-Well SECTOR Plate	2-8 °C	25 each (1 plate)
Diluent 100	2-8 °C	5 bottle (200 mL)
U-PLEX Stop Solution	2-8 °C	5 bottle (40 mL)
Diluent 3	≤-10 °C	5 bottle (40 mL)
Diluent 58	≤-10 °C	5 bottle (50 mL)
MSD GOLD Read Buffer B	RT	5 bottle (90 mL)

Kit Contents for Catalog No. K15339K-21

Product Description	Storage	Quantity per Kit
Human Angiogenesis Combo 1, Box 1 of 2 (1 PL)	Multi-Component	1 each (1 each)

Human Angiogenesis Combo 1, Box 2 of 2 (1 PL)	Multi-Component	1 each (1 each)

Kit Contents for Catalog No. K15339K-22

Product Description	Storage	Quantity per Kit
Human Angiogenesis Combo 1, Box 1 of 2 (5 PL)	Multi-Component	1 each (5 each)

Human Angiogenesis Combo 1, Box 2 of 2 (5 PL)	Multi-Component	1 each (5 each)

Kit Contents for Catalog No. K15339K-24

Product Description	Storage	Quantity per Kit
Human Angiogenesis Combo 1, Box 1 of 2 (25 PL)	Multi-Component	1 each (25 each)

Human Angiogenesis Combo 1, Box 2 of 2 (25 PL)	Multi-Component	1 each (25 each)

Order Details

K15339K

Select your instrument:

S 600

SQ 120

Q 60

Catalog No

Size

Price in USD

Qty

K15339K-1

1 plate size

$1,603.00

Usually ships in 1-3 days

K15339K-2

5 plate size

$6,406.00

Usually ships in 1-3 days

K15339K-4

25 plate size

$28,826.00

Usually ships in 1-3 days

K15339K-21

1 plate size

$2,088.00

Usually ships in 1-3 days

K15339K-22

5 plate size

$6,406.00

Usually ships in 1-3 days

K15339K-24

25 plate size

$28,826.00

Usually ships in 1-3 days

Customize

Contact Information

Customer Service/Orders
1-240-314-2795

5:00 a.m. to 8:00 p.m.
US Eastern Time

Email

Scientific/Technical Support
1-240-314-2798

8:30 a.m. to 5:30 p.m.
US Eastern Time

Email

Instrument Support
1-301-947-2057

8:30 a.m. - 5:30 p.m.
US Eastern Time

Email

Company Headquarters
1-240-314-2600
1601 Research Blvd.
Rockville, Maryland 20850-3173
USA

Product Inserts		U-PLEX I-O Group 1 (human) Multiplex Insert
Datasheets		U-PLEX Human FGF (basic) U-PLEX Human PlGF U-PLEX Human Tie-2 U-PLEX Human VEGF-A U-PLEX Human VEGF-D
Product Highlights		U-PLEX Platform Highlights
SDS		Biotin-conjugated Antibodies Safety Data Sheet Diluent 2, Diluent 3, Diluent 5, Diluent 7 and Diluent 8 Diluent 50, Diluent 56, Diluent 61, Diluent 100, and Diluent 101 Diluent 57, Diluent 58, and Diluent 59 MSD Calibrators and Controls MSD GOLD Read Buffer B U-PLEX Linker Set

Title	Journal	Year
Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection Najmeh Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu, Shima Shahbaz, Wendy Sligl, Mohammed Osman, Demetrios J. Kutsogiannis, Erika MacIntyre, Conar R. O’Neil, Shokrollah Elahi	mBio	2021
Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial G B Sigal, M R Segal, A Mathew, L Jarlsberg, M Wang, S Barbero, N Small, K Haynesworth, J L Davis, M Weiner, W C Whitworth, J Jacobs, J Schorey, D M Lewinsohn, P Nahid	EBioMedicine	2017
A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2 in patients with advanced hepatocellular cancer. Zhu AX, Finn RS, Mulcahy M, Gurtler J, Sun W, Schwartz JD, Dalal RP, Joshi A, Hozak RR, Xu Y, Ancukiewicz M, Jain RK, Nugent F, Duda DG, Stuart K.	Clin Cancer Res.	2013
Phase I study of Dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma. Angevin E, Lopez-Martin JA, Lin CC, Gschwend JE, Harzstark A, Castellano D, Soria JC, Sen P, Chang J, Shi M, Kay A, Escudier B.	Clin Cancer Res	2013
Effects of Sorafenib on Intra-Tumoral Interstitial Fluid Pressure and Circulating Biomarkers in Patients with Refractory Sarcomas (NCI Protocol 6948). Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK.	PLoS One.	2012
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NEW U-PLEX Angiogenesis Combo 1 (human)

Kit Contents for Catalog No. K15339K-1

Kit Contents for Catalog No. K15339K-2

Kit Contents for Catalog No. K15339K-4

Kit Contents for Catalog No. K15339K-21

Kit Contents for Catalog No. K15339K-22

Kit Contents for Catalog No. K15339K-24

Order Details

K15339K

S 600

SQ 120

Q 60

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