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p53 is a transcription factor whose activity is upregulated following DNA damage. Activation of p53 results in cell cycle arrest until DNA damage is repaired or in the activation of apoptosis if the cellular damage is too great. Mutations in the tumor suppressor p53 are found in nearly half of all human cancers. This kit provides assay-specific components for the quantitative determination of total p53 in human whole cell lysates.
Please note: MSD has transitioned this product to a status of “made-to-order” with a minimum order size of 25 plates. For an order of the 5-plate pack size, the minimum quantity is 5 packs (25 plates). The 1-plate and 20-plate pack sizes have been discontinued.
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Specifications
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Kit Contents
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Documentation
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References
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Application(s)
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Phosphoproteins
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Ubiquitinated Proteins
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Intracellular Signaling
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Oncology & Cancer
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Analyte(s)
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p53
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Species
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Human, Mouse, Rat
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Instrument(s)
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SECTOR Imager 2400
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MESO SECTOR S 600MM
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SECTOR Imager 6000
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MESO QuickPlex SQ 120MM
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MESO QuickPlex SQ 120
,
MESO SECTOR S 600
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Plate Type
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96-well
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Goat Polyclonal
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Kit Model
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Whole Cell Lysate
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Schedule B Code
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3822.19.0000
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Product Description
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Storage
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Quantity per Kit
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Phosphatase Inhibitor I 0.5mL
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2-8 °C
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1 each
(1 each)
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Phosphatase Inhibitor II 0.5mL
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2-8 °C
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1 each
(1 each)
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Protease Inhibitor Solution 0.5mL
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2-8 °C
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1 each
(1 each)
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SULFO-TAG Anti-Total p53 Antibody
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2-8 °C
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1 vial
(375 μL)
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Total p53 Plate
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2-8 °C
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5 each
(1 each)
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2-8 °C
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1 bottle
(50 mL)
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2-8 °C
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1 bottle
(200 mL)
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RT
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1 bottle
(50 mL)
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RT
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1 bottle
(15 g)
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RT
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1 bottle
(1 g)
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≤-10 °C
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1 vial
(0.2 mL)
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Product Inserts
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Datasheets
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SDS
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Title
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Journal
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Year
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Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233.
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Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.
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Multiplexing siRNAs to compress RNAi-based screen size in human cells.
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Order Details
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Price in USD
Qty
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