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S-PLEX is MSD’s ultrasensitive assay platform. It can dramatically improve the sensitivity of immunoassays, reducing the lower limit of detection (LLOD) by 10- to 1000-fold over other assay methods. The S-PLEX Neurology Panel 1 (human) Kit includes three biomarkers that are associated with neurodegenerative diseases (Table 1). The assays can be used for quantitative measurements in the sample types listed in the “Specifications” tab below and offer detection limits in the fg/mL range.
| Analyte |
Median LLOD |
Dynamic Range |
Unit |
| GFAP |
150 |
150 - 880,000 |
fg/mL |
| Neurofilament L |
930 |
930 - 4,330,000 |
fg/mL |
| Tau (total) |
37 |
37 - 153,000 |
fg/mL |
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Specifications
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Kit Contents
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Documentation
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References
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Application(s)
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Neurobiology/Neurodegeneration
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Analyte(s)
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GFAP, Neurofilament L, Tau (total)
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Species
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Human
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Instrument(s)
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SECTOR Imager 2400
,
MESO QuickPlex SQ 120MM
,
MESO SECTOR S 600
,
SECTOR Imager 6000
,
MESO SECTOR S 600MM
,
MESO QuickPlex SQ 120
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Plate Type
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96-well
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Sample Type
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Serum, Plasma, Cell Culture Supernatant, CSF
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Condition
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Multi-Component
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Schedule B Code
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3822.19.0000
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Product Description
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Storage
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Quantity per Kit
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S-PLEX Neurology Panel 1 (human) Calibrator Blend
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≤-70 °C
|
1 vial
(1 vial)
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S-PLEX Neurology Panel 1 (human) Coating Solution
|
≤-70 °C
|
1 vial
(1 vial)
|
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S-PLEX Detect D2
|
≤-70 °C
|
1 each
(50 μL)
|
|
|
|
S-PLEX Detect D1
|
≤-70 °C
|
1 each
(1.7 mL)
|
|
|
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TURBO-BOOST Human GFAP Antibody
|
2-8 °C
|
1 vial
(1 plate size)
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TURBO-BOOST Hu Neurofilament L Antibody
|
2-8 °C
|
1 vial
(1 plate size)
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TURBO-BOOST Human Tau Antibody
|
2-8 °C
|
1 vial
(1 plate size)
|
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S-PLEX Multiplex, 96-Well SECTOR Plate
|
2-8 °C
|
1 each
(1 each)
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|
|
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2-8 °C
|
1 each
(50 mL)
|
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Diluent 64
|
2-8 °C
|
1 bottle
(18 mL)
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|
RT
|
1 each
(18 mL)
|
|
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|
S-PLEX Enhance E1
|
≤-10 °C
|
1 each
(1.7 mL)
|
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S-PLEX Enhance E2
|
≤-10 °C
|
1 each
(1.7 mL)
|
|
|
|
S-PLEX Enhance E3
|
≤-70 °C
|
1 each
(50 μL)
|
|
|
|
|
≤-10 °C
|
1 each
(500 μL)
|
|
|
|
Blocker S2
|
≤-10 °C
|
1 vial
(500 μL)
|
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Product Description
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Storage
|
Quantity per Kit
|
|
S-PLEX Neurology Panel 1 (human) Calibrator Blend
|
≤-70 °C
|
5 vial
(1 vial)
|
|
|
|
S-PLEX Neurology Panel 1 (human) Coating Solution
|
≤-70 °C
|
5 vial
(1 vial)
|
|
|
|
S-PLEX Detect D2
|
≤-70 °C
|
5 each
(50 μL)
|
|
|
|
S-PLEX Detect D1
|
≤-70 °C
|
5 each
(1.7 mL)
|
|
|
|
TURBO-BOOST Human GFAP Antibody
|
2-8 °C
|
1 vial
(5 plate size)
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|
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TURBO-BOOST Hu Neurofilament L Antibody
|
2-8 °C
|
1 vial
(5 plate size)
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TURBO-BOOST Human Tau Antibody
|
2-8 °C
|
1 vial
(5 plate size)
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S-PLEX Multiplex, 96-Well SECTOR Plate
|
2-8 °C
|
5 each
(1 each)
|
|
|
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|
2-8 °C
|
1 each
(50 mL)
|
|
|
|
Diluent 64
|
2-8 °C
|
1 bottle
(90 mL)
|
|
|
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|
RT
|
1 each
(90 mL)
|
|
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S-PLEX Enhance E1
|
≤-10 °C
|
5 each
(1.7 mL)
|
|
|
|
S-PLEX Enhance E2
|
≤-10 °C
|
5 each
(1.7 mL)
|
|
|
|
S-PLEX Enhance E3
|
≤-70 °C
|
5 each
(50 μL)
|
|
|
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≤-10 °C
|
1 each
(500 μL)
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Blocker S2
|
≤-10 °C
|
1 vial
(500 μL)
|
|
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Product Description
|
Storage
|
Quantity per Kit
|
|
S-PLEX Neurology Panel 1 (human) Calibrator Blend
|
≤-70 °C
|
25 vial
(1 vial)
|
|
|
|
S-PLEX Neurology Panel 1 (human) Coating Solution
|
≤-70 °C
|
25 vial
(1 vial)
|
|
|
|
S-PLEX Detect D2
|
≤-70 °C
|
25 each
(50 μL)
|
|
|
|
S-PLEX Detect D1
|
≤-70 °C
|
25 each
(1.7 mL)
|
|
|
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TURBO-BOOST Human GFAP Antibody
|
2-8 °C
|
5 vial
(5 plate size)
|
|
|
|
TURBO-BOOST Hu Neurofilament L Antibody
|
2-8 °C
|
5 vial
(5 plate size)
|
|
|
|
TURBO-BOOST Human Tau Antibody
|
2-8 °C
|
5 vial
(5 plate size)
|
|
|
|
S-PLEX Multiplex, 96-Well SECTOR Plate
|
2-8 °C
|
25 each
(1 each)
|
|
|
|
|
2-8 °C
|
5 each
(50 mL)
|
|
|
|
Diluent 64
|
2-8 °C
|
5 bottle
(90 mL)
|
|
|
|
|
RT
|
5 each
(90 mL)
|
|
|
|
S-PLEX Enhance E1
|
≤-10 °C
|
25 each
(1.7 mL)
|
|
|
|
S-PLEX Enhance E2
|
≤-10 °C
|
25 each
(1.7 mL)
|
|
|
|
S-PLEX Enhance E3
|
≤-70 °C
|
25 each
(50 μL)
|
|
|
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≤-10 °C
|
5 each
(500 μL)
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|
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Blocker S2
|
≤-10 °C
|
5 vial
(500 μL)
|
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Product Inserts
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Product Highlights
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Certificate of analysis
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SDS
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Scientific Posters
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Title
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Journal
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Year
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Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome
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Plasma biomarkers for diagnosis of Alzheimer’s disease and prediction of cognitive decline in individuals with mild cognitive impairment
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Quantitation of neurofilament light chain protein in serum and cerebrospinal fluid from patients with multiple sclerosis using the MSD R-PLEX NfL assay
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Associations between prognostic index scores and plasma neurofilament light in Huntington's disease
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Elevation of neural injury markers in patients with neurologic sequelae after hospitalization for SARS-CoV-2 infection
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