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S-PLEX is MSD’s ultrasensitive assay platform. It can dramatically improve the sensitivity of immunoassays, reducing the lower limit of detection (LLOD) by 10- to 1000-fold over other assay methods. The S-PLEX Human Tau (total) Assay has the essential components for an ultrasensitive assay that measures Tau (total) in a single-analyte format. For detailed instructions on running the Tau (total) assay, please see the product insert in the "Documentation" tab below.
Related Key Terms: Neurobiology/Neurodegeneration, Total Tau protein, Tau, MAPT, DDPAC, MTBT2, PPND, PPP1R103
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Specifications
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Kit Contents
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Documentation
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References
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Application(s)
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Neurobiology/Neurodegeneration
,
Alzheimer’s Disease
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Analyte(s)
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Tau (total)
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Species
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Human
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Instrument(s)
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SECTOR Imager 2400
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MESO QuickPlex SQ 120MM
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MESO SECTOR S 600
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SECTOR Imager 6000
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MESO SECTOR S 600MM
,
MESO QuickPlex SQ 120
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Plate Type
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96-well
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Capture Antibody
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Mouse monoclonal
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Detection Antibody
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Mouse monoclonal
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LLOD (Sensitivity)
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37 fg/mL
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Dynamic Range
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37 - 207,000 fg/mL
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Sample Type
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Serum, Plasma, Cell Culture Supernatant, CSF
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Condition
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Multi-Component
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Gene ID(s)
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4137
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UniProt ID(s)
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P10636
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Schedule B Code
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3822.19.0000
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Product Description
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Storage
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Quantity per Kit
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S-PLEX Neurology Panel 1 (human) Calibrator Blend
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≤-70 °C
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1 vial
(1 vial)
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S-PLEX Neurology Panel 1 (human) Coating Solution
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≤-70 °C
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1 vial
(1 vial)
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S-PLEX Detect D2
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≤-70 °C
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1 each
(50 μL)
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S-PLEX Detect D1
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≤-70 °C
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1 each
(1.7 mL)
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TURBO-BOOST Human Tau Antibody
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2-8 °C
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1 vial
(1 plate size)
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S-PLEX Multiplex, 96-Well SECTOR Plate
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2-8 °C
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1 each
(1 each)
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2-8 °C
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1 bottle
(50 mL)
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Diluent 64
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2-8 °C
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1 bottle
(18 mL)
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RT
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1 bottle
(18 mL)
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S-PLEX Enhance E1
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≤-10 °C
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1 each
(1.7 mL)
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S-PLEX Enhance E2
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≤-10 °C
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1 vial
(1.7 mL)
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S-PLEX Enhance E3
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≤-70 °C
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1 each
(50 μL)
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≤-10 °C
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1 vial
(500 μL)
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Blocker S2
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≤-10 °C
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1 vial
(500 μL)
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Product Description
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Storage
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Quantity per Kit
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S-PLEX Neurology Panel 1 (human) Calibrator Blend
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≤-70 °C
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5 vial
(1 vial)
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S-PLEX Neurology Panel 1 (human) Coating Solution
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≤-70 °C
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5 vial
(1 vial)
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S-PLEX Detect D2
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≤-70 °C
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5 each
(50 μL)
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S-PLEX Detect D1
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≤-70 °C
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5 each
(1.7 mL)
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TURBO-BOOST Human Tau Antibody
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2-8 °C
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1 vial
(5 plate size)
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S-PLEX Multiplex, 96-Well SECTOR Plate
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2-8 °C
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5 each
(1 each)
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2-8 °C
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1 bottle
(50 mL)
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Diluent 64
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2-8 °C
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1 bottle
(90 mL)
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RT
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1 bottle
(90 mL)
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S-PLEX Enhance E1
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≤-10 °C
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5 each
(1.7 mL)
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S-PLEX Enhance E2
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≤-10 °C
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5 vial
(1.7 mL)
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S-PLEX Enhance E3
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≤-70 °C
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5 each
(50 μL)
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≤-10 °C
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1 vial
(500 μL)
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Blocker S2
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≤-10 °C
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1 vial
(500 μL)
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Product Description
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Storage
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Quantity per Kit
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S-PLEX Neurology Panel 1 (human) Calibrator Blend
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≤-70 °C
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25 vial
(1 vial)
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S-PLEX Neurology Panel 1 (human) Coating Solution
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≤-70 °C
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25 vial
(1 vial)
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S-PLEX Detect D2
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≤-70 °C
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25 each
(50 μL)
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S-PLEX Detect D1
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≤-70 °C
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25 each
(1.7 mL)
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TURBO-BOOST Human Tau Antibody
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2-8 °C
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5 vial
(5 plate size)
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S-PLEX Multiplex, 96-Well SECTOR Plate
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2-8 °C
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25 each
(1 each)
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2-8 °C
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5 bottle
(50 mL)
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Diluent 64
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2-8 °C
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5 bottle
(90 mL)
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RT
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5 bottle
(90 mL)
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S-PLEX Enhance E1
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≤-10 °C
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25 each
(1.7 mL)
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S-PLEX Enhance E2
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≤-10 °C
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25 vial
(1.7 mL)
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S-PLEX Enhance E3
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≤-70 °C
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25 each
(50 μL)
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≤-10 °C
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5 vial
(500 μL)
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Blocker S2
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≤-10 °C
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5 vial
(500 μL)
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Product Inserts
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Product Highlights
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Certificate of analysis
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SDS
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Title
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Journal
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Year
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Plasma biomarkers for diagnosis of Alzheimer’s disease and prediction of cognitive decline in individuals with mild cognitive impairment
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Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein.
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High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia.
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Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models.
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The AD-CSF-Index discriminates Alzheimer's disease patients from healthy controls: A validation study
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