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The Kidney Injury Panel 1 (rat) Kit provides the assay-specific components for the quantitative determination of both natural and recombinant rat NGAL/LCN2 (neutrophil gelatinase-associated lipocalin; lipocalin-2), osteopontin (OPN), albumin, and HAVCR1/KIM-1 (hepatitis A virus cellular receptor 1; kidney injury molecule 1) also known as TIM-1 (T cell immunoglobulin- and mucin domain-containing molecule 1) in urine samples.
NGAL/LCN2 is a 25 kDa glycoprotein that acts as a transport protein carrying small hydrophobic molecules such as steroid hormones, vitamins, and metabolic products. It is expressed in most tissues and is induced in epithelial cells upon inflammation. In the kidney, NGAL/LCN2 may be implicated in both the progress of and protection from renal injury. OPN is a secreted acidic and phosphorylated glycoprotein that is involved in bone metabolism, immune regulation, cell survival, and tumor progression. OPN is mostly expressed in bone, kidney, and epithelial tissues. Albumin is the most abundant serum protein and acts as a transport protein for hemin and fatty acids. Albumin is produced in the liver and secreted into the bloodstream. HAVCR1/KIM-1 is a type 1 transmembrane glycoprotein found on CD4+ T cells and renal proximal tubule epithelial cells. HAVCR1/KIM-1 is released upon certain types of acute kidney, and can be measured in urine, serum, or plasma.
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Specifications
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Kit Contents
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Documentation
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References
Application(s)
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Cytokines & Chemokines
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Toxicology
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Kidney Injury
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Immunology/Inflammation
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Analyte(s)
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Albumin, HAVCR1/KIM-1, NGAL/LCN2, Osteopontin
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Species
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Rat
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Instrument(s)
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SECTOR Imager 2400
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MESO SECTOR S 600MM
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SECTOR Imager 6000
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MESO QuickPlex SQ 120MM
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MESO QuickPlex SQ 120
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MESO SECTOR S 600
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Plate Type
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96-well
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Condition
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Multi-Component
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Schedule B Code
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3822.19.0000
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Product Description
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Storage
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Quantity per Kit
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Kidney Injury Panel 1 (rat) Calibrator Blend
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≤-70 °C
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1 vial (15 μL)
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SULFO-TAG Anti-Albumin Tracer Antibody
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2-8 °C
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1 vial (1 vial)
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SULFO-TAG Anti-rat Osteopontin Antibody
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2-8 °C
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1 vial (75 μL)
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SULFO-TAG Anti-rat Lipocalin-2 Antibody
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2-8 °C
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1 vial (75 μL)
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SULFO-TAG Anti-rat TIM-1/KIM-1/HAVCR Antibody
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2-8 °C
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1 vial (75 μL)
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Kidney Injury Panel 1 (rat) Plate
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2-8 °C
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1 each (1 each)
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≤-10 °C
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1 bottle (15 mL)
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RT
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1 bottle (50 mL)
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MSD Blocker A
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RT
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1 bottle (250 mL)
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MSD Phosphate Buffer 5X
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RT
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1 bottle (50 mL)
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Product Description
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Storage
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Quantity per Kit
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Kidney Injury Panel 1 (rat) Calibrator Blend
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≤-70 °C
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5 vial (15 μL)
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SULFO-TAG Anti-Albumin Tracer Antibody
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2-8 °C
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1 vial
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SULFO-TAG Anti-rat Osteopontin Antibody
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2-8 °C
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1 vial (375 μL)
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SULFO-TAG Anti-rat Lipocalin-2 Antibody
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2-8 °C
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1 vial (375 μL)
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SULFO-TAG Anti-rat TIM-1/KIM-1/HAVCR Antibody
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2-8 °C
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1 vial (375 μL)
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Kidney Injury Panel 1 (rat) Plate
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2-8 °C
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5 each (1 each)
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≤-10 °C
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2 bottle (40 mL)
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RT
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1 bottle (50 mL)
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MSD Blocker A
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RT
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1 bottle (250 mL)
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MSD Phosphate Buffer 5X
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RT
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1 bottle (50 mL)
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Product Description
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Storage
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Quantity per Kit
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Kidney Injury Panel 1 (rat) Calibrator Blend
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≤-70 °C
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25 vial (15 μL)
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SULFO-TAG Anti-Albumin Tracer Antibody
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2-8 °C
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5 vial
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SULFO-TAG Anti-rat Osteopontin Antibody
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2-8 °C
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5 vial (375 μL)
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SULFO-TAG Anti-rat Lipocalin-2 Antibody
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2-8 °C
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5 vial (375 μL)
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SULFO-TAG Anti-rat TIM-1/KIM-1/HAVCR Antibody
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2-8 °C
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5 vial (375 μL)
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Kidney Injury Panel 1 (rat) Plate
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2-8 °C
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25 each (1 each)
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≤-10 °C
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10 bottle (40 mL)
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RT
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5 bottle (50 mL)
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MSD Blocker A
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RT
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5 bottle (250 mL)
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MSD Phosphate Buffer 5X
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RT
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5 bottle (50 mL)
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Product Inserts
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Certificate of analysis
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SDS
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Scientific Posters
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Title
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Journal
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Year
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Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial
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Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.
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Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats.
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Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics.
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Assessment of cisplatin-induced kidney injury using an integrated rodent platform.
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