Click image to enlarge
Immunoglobulins (Ig) are critical components of the immune system and play a major role in eliciting the body's immune response against pathogens. Five heavy-chain isotypes (IgA, IgD, IgE, IgG, and IgM) mediate specific biological functions, including responses to pathogens and immunological diseases such as allergies and autoimmune disorders. IgA has two subclasses (IgA1 and IgA2) and exists in both monomeric and dimeric forms. It is approximately 15% of the total serum Ig content. Secretory IgA is a dimer that provides the primary defense against localized infections. High levels of IgA are often found in samples from subjects with chronic infections such as cirrhotic liver disease. IgG, a monomer, is the dominant immunoglobulin class present in serum. Increased IgG is commonly seen in samples from subjects with humoral immunodeficiencies, autoimmune diseases, liver diseases, chronic inflammatory diseases, haematological disorders, infections, and lymphoid malignancies. IgM is a pentamer that comprises approximately 10% of serum immunoglobulin content. IgM level is often increased in samples from subjects with infectious diseases including primary biliary cirrhosis, infectious mononucleosis, cytomegalovirus infection, and tuberculosis. This kit provides the assay-specific components for the quantitative determination of IgA, IgG, and IgM in human, cynomolgus monkey, and rhesus monkey sera samples.
-
-
Specifications
-
Kit Contents
-
Documentation
-
References
Application(s)
|
|
Assay Development
|
|
Analyte(s)
|
|
IgA, IgG, IgM
|
|
Species
|
|
Human, Non-human primate
|
|
Instrument(s)
|
|
SECTOR Imager 2400
,
MESO SECTOR S 600MM
,
SECTOR Imager 6000
,
MESO QuickPlex SQ 120MM
,
MESO QuickPlex SQ 120
,
MESO SECTOR S 600
|
|
Plate Type
|
|
96-well
|
|
Usage Statement
|
|
For Research Use Only. Not for use in diagnostic procedures.
|
|
Storage Condition
|
|
Multi-Component
|
|
Schedule B Code
|
|
3822.19.0000
|
|
Product Description
|
Storage
|
Quantity per Kit
|
Isotyping Panel 1 (Human/NHP) Calibrator Blend
|
≤-70 °C
|
1 vial (1 vial)
|
|
Human/NHP IgA Antibody, 1 Plate
|
2-8 °C
|
1 vial
|
|
Human/NHP IgG Antibody, 1 Plate
|
2-8 °C
|
1 vial
|
|
Human/NHP IgM Antibody, 1 Plate
|
2-8 °C
|
1 vial
|
|
Isotyping Panel 1 (Human/NHP) Plate
|
2-8 °C
|
1 each (1 each)
|
|
|
2-8 °C
|
1 bottle (200 mL)
|
|
|
RT
|
1 bottle (50 mL)
|
|
MSD Blocker A
|
RT
|
1 bottle (250 mL)
|
|
MSD Phosphate Buffer 5X
|
RT
|
1 bottle (50 mL)
|
|
Product Description
|
Storage
|
Quantity per Kit
|
Isotyping Panel 1 (Human/NHP) Calibrator Blend
|
≤-70 °C
|
5 vial (1 vial)
|
|
Human/NHP IgA Antibody, 5 Plate
|
2-8 °C
|
1 vial
|
|
Human/NHP IgG Antibody, 5 Plate
|
2-8 °C
|
1 vial
|
|
Human/NHP IgM Antibody, 5 Plate
|
2-8 °C
|
1 vial
|
|
Isotyping Panel 1 (Human/NHP) Plate
|
2-8 °C
|
5 each (1 each)
|
|
|
2-8 °C
|
1 bottle (1000 mL)
|
|
|
RT
|
1 bottle (50 mL)
|
|
MSD Blocker A
|
RT
|
1 bottle (250 mL)
|
|
MSD Phosphate Buffer 5X
|
RT
|
1 bottle (50 mL)
|
|
Product Description
|
Storage
|
Quantity per Kit
|
Isotyping Panel 1 (Human/NHP) Calibrator Blend
|
≤-70 °C
|
25 vial (1 vial)
|
|
Human/NHP IgA Antibody, 5 Plate
|
2-8 °C
|
5 vial
|
|
Human/NHP IgG Antibody, 5 Plate
|
2-8 °C
|
5 vial
|
|
Human/NHP IgM Antibody, 5 Plate
|
2-8 °C
|
5 vial
|
|
Isotyping Panel 1 (Human/NHP) Plate
|
2-8 °C
|
25 each (1 each)
|
|
|
2-8 °C
|
5 bottle (1000 mL)
|
|
|
RT
|
5 bottle (50 mL)
|
|
MSD Blocker A
|
RT
|
5 bottle (250 mL)
|
|
MSD Phosphate Buffer 5X
|
RT
|
5 bottle (50 mL)
|
|
Product Inserts
|
|
|
Certificate of analysis
|
|
|
SDS
|
|
|
Title
|
Journal
|
Year
|
|
Age-Associated Seroprevalence of Coronavirus Antibodies: Population-Based Serosurveys in 2013 and 2020, British Columbia, Canada
|
|
|
|
IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare Workers
|
|
|
|
MSD-based assays facilitate a rapid and quantitative serostatus profiling for the presence of anti-AAV antibodies
|
|
|
|
Clinical Performance of Three Commercial and Two In-House Multiplex Assays for SARS-CoV-2 Antibody Detection in Dried Blood Spot Specimens
|
|
|
|
SARS-CoV-2 Nucleocapsid Plasma Antigen for Diagnosis and Monitoring of COVID-19
|
|
|
|
View All
|
Order Details
Catalog No
Size
Price in USD
Qty
Customer Service/Orders
Scientific/Technical Support
Instrument Support
Company Headquarters