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U-PLEX Multiple Sclerosis Combo 1 (human)

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U-PLEX Combos offer popular panels of biomarkers that have been grouped together for convenient ordering. They have been tested for multiplex compatibility and are fulfilled as a kit. The U-PLEX Multiple Sclerosis Combo 1 (human) contains assays for 9 inflammatory biomarkers associated with MS into a single assay (Table 1). The assays can be used for quantitative measurements in the sample types listed in the "Specifications" tab below, and offer detection limits (LLODs) in the sub- to low pg/mL range.

Table 1. List of analytes and typical detection limits

Analyte	LLOD - ULOD	units
CTACK	1.8 - 4,200	pg/mL
Fractalkine	100 - 181,000	pg/mL
GRO-α	0.25 - 2,500	pg/mL
IL-7	1.5 - 7,040	pg/mL
IL-12/IL-23p40	2.8 - 21,000	pg/mL
IP-10	0.49 - 6,000	pg/mL
MCP-1	0.74 - 6,600	pg/mL
MIP-1β	1.5 - 1,640	pg/mL
MIP-3α	1.8 - 20,800	pg/mL

Specifications
Kit Contents
Documentation
References

Analyte(s)		CTACK, Fractalkine, GRO-α, IL-7, IL-12/IL-23p40, IP-10, MCP-1, MIP-1β, MIP-3α
Species		Human
Instrument(s)		SECTOR Imager 2400 , MESO QuickPlex SQ 120MM , MESO SECTOR S 600 , SECTOR Imager 6000 , MESO SECTOR S 600MM , MESO QuickPlex SQ 120
U-PLEX Group Compatibility		Biomarker Group 1
Plate Type		96-well
Sample Type		Plasma, CSF, Serum
Usage Statement		For Research Use Only. Not for use in diagnostic procedures.
Storage Statement(s)		Please refer to the product insert for the storage conditions of individual kit components.
Storage Condition		Multi-Component
Schedule B Code		3822.19.0000

Product Description	Storage	Quantity per Kit
U-PLEX Linker Set, 9-Assay (300 µL)	2-8 °C	1 each (1 vial)

U-PLEX Human IP-10 Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human MCP-1 Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human MIP-1β Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human IL-7 Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human IL-12/IL-23p40 Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human GRO-α Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human MIP-3α Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human Fractalkine Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

U-PLEX Human CTACK Antibody Set (1 Plate Size)	2-8 °C	1 each (1 plate size)

Calibrator 2	2-8 °C	1 vial (1 vial)

Calibrator 3	2-8 °C	1 vial (1 vial)

Calibrator 4	2-8 °C	1 vial (1 vial)

Calibrator 10	2-8 °C	1 vial (1 vial)

U-PLEX 9-Assay, 96-Well SECTOR Plate	2-8 °C	1 each (1 plate)

U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)

Diluent 3	≤-10 °C	1 bottle (8 mL)

Diluent 57	≤-10 °C	1 bottle (50 mL)

MSD GOLD Read Buffer B	RT	1 bottle (18 mL)

Product Description	Storage	Quantity per Kit
U-PLEX Linker Set, 9-Assay (1.8 mL)	2-8 °C	1 each (1 vial)

U-PLEX Human IP-10 Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human MCP-1 Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human MIP-1β Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human IL-7 Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human IL-12/IL-23p40 Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human GRO-α Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human MIP-3α Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human Fractalkine Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

U-PLEX Human CTACK Antibody Set (5 Plate Size)	2-8 °C	1 each (5 plate size)

Calibrator 2	2-8 °C	5 vial (1 vial)

Calibrator 3	2-8 °C	5 vial (1 vial)

Calibrator 4	2-8 °C	5 vial (1 vial)

Calibrator 10	2-8 °C	5 vial (1 vial)

U-PLEX 9-Assay, 96-Well SECTOR Plate	2-8 °C	5 each (1 plate)

U-PLEX Stop Solution	2-8 °C	1 bottle (40 mL)

Diluent 3	≤-10 °C	1 bottle (40 mL)

Diluent 57	≤-10 °C	1 bottle (50 mL)

MSD GOLD Read Buffer B	RT	1 bottle (90 mL)

Product Description	Storage	Quantity per Kit
U-PLEX Linker Set, 9-Assay (1.8 mL)	2-8 °C	5 each (1 vial)

U-PLEX Human IP-10 Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human MCP-1 Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human MIP-1β Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human IL-7 Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human IL-12/IL-23p40 Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human GRO-α Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human MIP-3α Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human Fractalkine Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

U-PLEX Human CTACK Antibody Set (5 Plate Size)	2-8 °C	5 each (5 plate size)

Calibrator 2	2-8 °C	25 vial (1 vial)

Calibrator 3	2-8 °C	25 vial (1 vial)

Calibrator 4	2-8 °C	25 vial (1 vial)

Calibrator 10	2-8 °C	25 vial (1 vial)

U-PLEX 9-Assay, 96-Well SECTOR Plate	2-8 °C	25 each (1 plate)

U-PLEX Stop Solution	2-8 °C	5 bottle (40 mL)

Diluent 3	≤-10 °C	5 bottle (40 mL)

Diluent 57	≤-10 °C	5 bottle (50 mL)

MSD GOLD Read Buffer B	RT	5 bottle (90 mL)

Order Details

Catalog No

Size

Price in USD

Qty

K15684K-1

1 plate size

$2,413.00

Planned: 3 Day Delivery

K15684K-2

5 plate size

$9,652.00

Planned: 3 Day Delivery

K15684K-4

25 plate size

$38,606.00

Planned: 3 Day Delivery

Contact Information

Customer Service/Orders
1-240-314-2795

5:00 a.m. to 8:00 p.m.
US Eastern Time

Email

Scientific/Technical Support
1-240-314-2798

5:30 a.m. to 5:30 p.m.
US Eastern Time

Email

Instrument Support
1-301-947-2057

8:30 a.m. - 5:30 p.m.
US Eastern Time

Email

Company Headquarters
1-240-314-2600
1601 Research Blvd.
Rockville, Maryland 20850-3173
USA

Product Inserts		U-PLEX Biomarker Group 1 (human) Multiplex Insert
Datasheets		U-PLEX Human CTACK U-PLEX Human Fractalkine U-PLEX Human GRO-α U-PLEX Human IL-12/IL-23p40 U-PLEX Human IL-7 U-PLEX Human IP-10 U-PLEX Human MCP-1 View More
Product Highlights		U-PLEX Platform Highlights
SDS		Biotin-conjugated Antibodies Safety Data Sheet Diluent 2, Diluent 3, Diluent 5, Diluent 7 and Diluent 8 Diluent 57, Diluent 58, and Diluent 59 MSD Calibrators and Controls MSD GOLD Read Buffer B U-PLEX Linker Set

Title	Journal	Year
Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection Najmeh Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu, Shima Shahbaz, Wendy Sligl, Mohammed Osman, Demetrios J. Kutsogiannis, Erika MacIntyre, Conar R. O’Neil, Shokrollah Elahi	mBio	2021
Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, Xue Manz, Jurjan Aman, Amsterdam UMC COVID-19 Biobank, Peter Bonta, Philip Brouwer, Steven de Taeye, Tom Caniels, Karlijn van der Straten, Korneliusz Golebski, Guillermo Griffith, René Jonkers, Mads Larsen, Federica Linty, Annette Neele, Jan Nouta, Frank van Baarle, Cornelis van Drunen, Alexander Vlaar, Godelieve de Bree, Rogier Sanders, Lisa Willemsen, Manfred Wuhrer, Harm Jan Bogaard, Marit van Gils, Gestur Vidarsson, Menno de Winther, Jeroen den Dunnen	TBD	2020
Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics Alpana Waghmare, Elizabeth M Krantz, Subhasish Baral, Emma Vasquez, Tillie Loeffelholz, E. Lisa Chung, Urvashi Pandey, Jane Kuypers, Elizabeth R Duke, Keith R Jerome, Alexander L Greninger, Daniel B Reeves, Florian Hladik, E Fabian Cardozo-Ojeda, Michael Boeckh, Joshua T Schiffer	TBD	2020
Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial G B Sigal, M R Segal, A Mathew, L Jarlsberg, M Wang, S Barbero, N Small, K Haynesworth, J L Davis, M Weiner, W C Whitworth, J Jacobs, J Schorey, D M Lewinsohn, P Nahid	EBioMedicine	2017
CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer’s disease Jonathan D. Cherry , Thor D. Stein, Yorghos Tripodis, Victor E. Alvarez, Bertrand R. Huber, Rhoda Au, Patrick T. Kiernan, Daniel H. Daneshvar, Jesse Mez, Todd M. Solomon, Michael L. Alosco, Ann C. McKee	PLOS ONE	2017
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U-PLEX Multiple Sclerosis Combo 1 (human)

Kit Contents for Catalog No. K15684K-1

Kit Contents for Catalog No. K15684K-2

Kit Contents for Catalog No. K15684K-4

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