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Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14. Marr, N., Hajjar, A.M., Shah, N.R., Novikov, A., Yam, C.S., Caroff, M., Fernandez, R.C. | Infect Immun. | 2010 | View |
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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Villareal, D.T., Robertson, H., Bell, G.I., Patterson, B.W., Tran, H., Wice, B., Polonsky, K.S. | Diabetes | 2010 | View |
The 4q12 Amplicon in Malignant Peripheral Nerve Sheath Tumors: Consequences on Gene Expression and Implications for Sunitinib Treatment. Zietsch, J., Ziegenhagen, N., Heppner, F.L., Reuss, D., von Deimling, A., Holtkamp, N. | PLoS One | 2010 | View |
The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. Betts, A.M., Clark, T.H., Yang, J., Treadway, J.L., Li, M., Giovanelli, M.A., Abdiche, Y., Stone, D.M., Paralkar, V.M. | J Pharmacol Exp Ther. | 2010 | View |
The Effect of Leflunomide on Cycling and Activation of T-Cells in HIV-1-Infected Participants. Read, S.W., DeGrezia, M., Ciccone, E.J., DerSimonian, R., Higgins, J., Adelsberger, J.W., Starling, J.M., Rehm, C., Sereti, I. | PLoS ONE | 2010 | View |
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The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing. Wanngren, J., Frånberg, J., Svensson, A.I., Laudon, H., Olsson, F., Winblad, B., Liu, F., Näslund, J., Lundkvist, J., Karlström, H. | J Biol Chem | 2010 | View |
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The relationship between neonatal blood protein profiles and placenta histologic characteristics in extremely low gestation age newborns. Hecht, J.L., Fichorova, R.N., Tang, V.F., Allred, E.N., McElrath, T.F., Leviton, A; for the ELGAN study investigators. | Pediatr Res. | 2010 | View |
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Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection. Ford, E.S., Greenwald, J.H., Richterman, A.G., Rupert, A., Dutcher, L., Badralmaa, Y., Natarajan, V., Rehm, C., Hadigan, C., Sereti, I. | AIDS | 2010 | View |
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