| References | Journal | Year | |
Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor.
May, P.C., Dean, R.A., Lowe, S.L., Martenyi, F., Sheehan, S.M., Boggs, L.N., Monk, S.A., Mathes, B.M., Mergott, D.J., Watson, B.M., Stout, S.L., Timm, D.E., Labell, S.E., Gonzales, C.R., Nakano, M., Jhee, S.S., Yen, M., Ereshefsky, L., Lindstrom, T.D., Calligaro, D.O., Cocke, P.J., Hall, G.D., Friedrich, S., Citron, M., Audia, J.E. | J Neurosci. | 2011 | View |
Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Horowitz, N.S., Penson, R.T., Duda, D.G., di Tomaso, E., Boucher, Y., Ancukiewicz, M., Cohen, K.S., Berlin, S., Krasner, C.N., Moses, M.A., Jain, R.K. | Clin Ovarian Cancer Other Gynecol Malig. | 2011 | View |
Safety evaluation of chronic intrathecal administration of idursulfase-IT in cynomolgus monkeys.
Felice, B.R., Wright, T.L., Boyd, R.B., Butt, M.T., Pfeifer, R.W., Pan, J., Ruiz, J.A., Heartlein, M.W., Calias, P. | Toxicol Pathol. | 2011 | View |
Serum protein profiling of systemic lupus erythematosus and systemic sclerosis using recombinant antibody microarrays.
Carlsson, A., Wuttge, D.M., Ingvarsson, J., Bengtsson, A.A., Sturfelt, G., Borrebaeck, C.A., Wingren, C. | Mol Cell Proteomics. | 2011 | View |
Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study.
Aronis, K.N., Vamvini, M.T., Chamberland, J.P., Sweeney, L.L., Brennan, A.M., Magkos, F., Mantzoros, C.S. | Metabolism. | 2011 | View |
Single and combination herpes simplex virus type 2 glycoprotein vaccines adjuvanted with CpG oligodeoxynucleotides or monophosphoryl lipid A exhibit differential immunity that is not correlated to protection in animal models.
Khodai, T., Chappell, D., Christy, C., Cockle, P., Eyles, J., Hammond, D., Gore, K., McCluskie, M.J., Evans, D.M., Lang, S., Loudon, P.T., Townend, T., Wright, P., West, K., Bright, H. | Clin Vaccine Immunol. | 2011 | View |
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis.
Muise, A.M., Walters, T., Xu, W., Shen-Tu, G., Guo, C.H., Fattouh, R., Lam, G.Y., Wolters, V.M., Bennitz, J., van Limbergen, J., Renbaum, P., Kasirer, Y., Ngan, B.Y., Turner, D., Denson, L.A., Sherman, P.M., Duerr, R.H., Cho, J., Lees, C.W., Satsangi, J., Wilson, D.C., Paterson, A.D., Griffiths, A.M., Glogauer, M., Silverberg, M.S., Brumell, J.H. | Gastroenterology. | 2011 | View |
Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody.
Padhi, D., Jang, G., Stouch, B., Fang, L., Posvar, E | JBMR | 2011 | View |
SirT1 Regulates Adipose Tissue Inflammation.
Gillum, M.P., Kotas, M.E., Erion, D.M., Kursawe, R., Chatterjee, P., Nead, K.T., Muise, E.S., Hsiao, J.J., Frederick, D.W., Yonemitsu, S., Banks, A.S., Qiang, L., Bhanot, S., Olefsky, J.M., Sears, D.D., Caprio, S., Shulman, G.I. | Diabetes. | 2011 | View |
Small molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity.
Lan, H., Cheng, C.C., Kowalski, T.J., Pang, L., Shan, L., Chuang, C.C., Jackson, J., Rojas-Triana, A., Bober, L., Liu, L., Voigt, J., Orth, P., Yang, X., Shipps, G.W. Jr, Hedrick, J.A. | J Lipid Res. | 2011 | View |
Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE(-/-) mice.
Bernberg E, Ulleryd MA, Johansson ME, Bergström GM. | Atherosclerosis | 2011 | View |
Soluble Beta-Amyloid Precursor Protein Is Related to Disease Progression in Amyotrophic Lateral Sclerosis.
Steinacker, P., Fang, L., Kuhle, J., Petzold, A., Tumani, H., Ludolph, A.C., Otto, M., Brettschneider, J. | PLoS ONE | 2011 | View |
Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.
Tamboli, I.Y., Hampel, H., Tien, N.T., Tolksdorf, K., Breiden, B., Mathews, P.M., Saftig, P., Sandhoff, K., Walter, J. | J Neurosci. | 2011 | View |
Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity.
Dong, J., Sereno, A., Snyder, W.B., Miller, B.R., Tamraz, S., Doern, A., Favis, M., Wu, X., Tran, H., Langley, E., Joseph, I., Boccia, A., Kelly, R., Wortham, K., Wang, Q., Berquist, L., Huang, F., Gao, S.X., Zhang, Y., Lugovskoy, A., Martin, S., Gouvis, H., Berkowitz, S., Chiang, G., Reff, M., Glaser, S.M., Hariharan, K., Demarest, S.J. | J Biol Chem. | 2011 | View |
Surface molecules on stimulated plasmacytoid dendritic cells are sufficient to cross-activate resting myeloid dendritic cells.
Cantisani, R., Sammicheli, C., Tavarini, S., D'Oro, U., Wack, A., Piccioli, D. | Hum Immunol. | 2011 | View |
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans.
Caskey M, Lefebvre F, Filali-Mouhim A, Cameron MJ, Goulet JP, Haddad EK, Breton G, Trumpfheller C, Pollak S, Shimeliovich I, Duque-Alarcon A, Pan L, Nelkenbaum A, Salazar AM, Schlesinger SJ, Steinman RM, Sékaly RP. | J Exp Med. | 2011 | View |
Systemic responses of preterm newborns with presumed or documented bacteremia.
Leviton, A., O'Shea, M.T., Bednarek, F.J., Allred, E.N., Fichorova, R.N., Dammann, O.; for the ELGAN Study Investigators. | Acta Paediatr. | 2011 | View |
Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage.
Patel, L., Sun, W., Glasson, S.S., Morris, E.A., Flannery, C.R., Chockalingam, P.S. | BMC Musculoskelet Disord. | 2011 | View |
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S.D., Bernardini, S., et al. | Alzheimers Dement. | 2011 | View |
The Antagonists But Not Partial Agonists of Glucocorticoid Receptor Ligands Show Substantial Side Effect Dissociation.
Hu, X., Du, S., Tunca, C., Braden, T., Long, K.R., Lee, J., Webb, E.G., Dietz, J.D., Hummert, S., Rouw, S., Hegde, S.G., Webber, R.K., Obukowicz, M.G. | Endocrinology | 2011 | View |
The biochemical response to biomechanical tissue loading on the low back during physical work exposure.
Yang, G., Marras, W.S., Best, T.M. | Clin Biomech (Bristol, Avon). | 2011 | View |
The effect of antioxidant supplementation on insulin-sensitivity in response to endurance exercise training.
Yfanti, C., Nielsen, A.R., Akerstrom, T.C., Nielsen, S., Rose, A.J., Richter, E.A., Lykkesfeldt, J., Fischer, C.P., Pedersen, B.K. | Am J Physiol Endocrinol Metab. | 2011 | View |
The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21.
Gupte, J., Yang, L., Wu, X., Weiszmann, J., Hecht, R., Lemon, B., Lindberg, R., Wang, Z., Li, Y. | J Mol Biol. | 2011 | View |
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by b1 cells.
Hams, E., Saunders, S.P., Cummins, E.P., O'Connor, A., Tambuwala, M.T., Gallagher, W.M., Byrne, A., Campos-Torres, A., Moynagh, P.M., Jobin, C., Taylor, C.T., Fallon, P.G. | Shock | 2011 | View |
The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691).
Fidock, M.D., Souberbielle, B.E., Laxton, C., Rawal, J., Delpuech-Adams, O., Corey, T.P., Colman, P., Kumar, V., Cheng, J.B., Wright, K., Srinivasan, S., Rana, K., Craig, C., Horscroft, N., Perros, M., Westby, M., Webster, R., van der Ryst, E. | Clin Pharmacol Ther. | 2011 | View |