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Pharmacological characterization of a small-molecule inhibitor of c-Jun kinase.
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Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets.
Waddleton, D., Wu, W., Feng, Y., Thompson, C., Wu, M., Zhou, Y.P., Howard, A., Thornberry, N., Li, J., Mancini, J.A. | Biochemical Pharmacology | 2008 | View |
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model.
Cacucci ,F., Yi M., Wills, T.J., Chapman, P., O'Keefe, J. | PNAS | 2008 | View |
Plasma PCSK9 Concentrations Correlate with LDL and Total Cholesterol in Diabetic Patients and Are Decreased by Fenofibrate Treatment.
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Practical approaches to proteomic biomarkers within prostate cancer radiotherapy trials.
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Protein kinase B/Akt activity is involved in renal TGF-{beta}1-driven epithelial-mesenchymal transition in vitro and in vivo.
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Protein Microarray Technologies for Detection and Identification of Bacterial and Protein Analytes in Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems.(Book Chapter)
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Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients.
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Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response.
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RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice.
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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial.
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Simultaneous Detection of Eight Analytes in Human Serum by Two Commercially Available Platforms for Multiplex Cytokine Analysis.
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Structural and functional characterization of disulfide isoforms of the human IGG2 subclass.
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Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.
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Survey of retail milk composition as affected by label claims regarding farm-management practices.
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The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells.
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The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells.
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The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane-monocyte contact bioassay.
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The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer.
Folkes, A.J., Ahmadi, K., Alderton, W.K., Alix, S., Baker, S.J., Box, G., Chuckowree, I.S., Clarke, P.A., Depledge, P., Eccles, S.A., Friedman, L.S., Hayes, A., Hancox, T.C., Kugendradas, A., Lensun, L., Moore, P., Olivero, A.G., Pang, J., Patel, S., Pergl-Wilson, G.H., Raynaud, F.I., Robson, A., Saghir, N., Salphati, L., Sohal, S., Ultsch, M.H., Valenti, M., Wallweber, H.J., Wan, N.C., Wiesmann, C., Workman, P., Zhyvoloup, A., Zvelebil, M.J., Shuttleworth, S.J. | J Med Chem. | 2008 | View |
The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium.
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The Stem Cell Marker CD133 (Prominin-1) Is Expressed in Various Human Glandular Epithelia.
Karbanova, J., Missol-Kolka, E., Fonseca, A.V., Lorra, C., Janich, P., Hollerova, H., Jaszai, J., Ehrmann, J., Kolar, Z., Liebers, C., Arl, S., Subrtova, D., Freund, D., Mokry, J., Huttner, W.B., Corbeil, D. | J Hist Cytochem. | 2008 | View |
The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection.
Tran, T.A., McCoy, M.K., Sporn, M.B., Tansey, M.G. | J Neuroinflammation. | 2008 | View |
TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN.
Inglefield, J.R., Dumitru, C.D., Alkan, S.S., Gibson, S.J., Lipson, K.E., Tomai, M.A., Larson, C.J., Vasilakos, J.P. | J Interferon Cytokine Res. | 2008 | View |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Fitzgerald, P., Cassidy Eugene, M., Clarke, G., Scully, P., Barry, S., Quigley Eamonn, M.M., Shanahan, F., Cryan, J., Dinan, T. G. | Neurogastroenterol Motil. | 2008 | View |