A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study.

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A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study.

Hirata S, Dirven L, Shen Y, Centola M, Cavet G, Lems WF, Tanaka Y, Huizinga TW, Allaart CF.

Journal		Rheumatology (Oxford)
Species
Analytes Measured		CRP , EGF , IL-6 , Leptin , MMP-1 , MMP-3 total , Resistin , SAA , TNF-RI , VCAM-1 , Flt-1 VEGFR1 , YKL-40
Matrix Tested		Serum

Year		2013
Volume
Page Numbers
Application		Cytokines and Chemokines , Metabolic

Abstract

Objective: To evaluate a multi-biomarker disease activity (MBDA) score, a novel index based on 12 serum proteins, as a tool to guide management of RA patients.

Methods: A total of 125 patients with RA from the Behandel Strategieën study were studied. Clinical data and serum samples were available from 179 visits, 91 at baseline and 88 at year 1. In each serum sample, 12 biomarkers were measured by quantitative multiplex immunoassays and the concentrations were used as input to a pre-specified algorithm to calculate MBDA scores.

Results: MBDA scores had significant correlation with DAS28-ESR (Spearman's ρ = 0.66, P < 0.0001) and also correlated with simplified disease activity index, clinical disease activity index and HAQ Disability Index (all P < 0.0001). Changes in MBDA between baseline and year 1 were also correlated with changes in DAS28-ESR (ρ = 0.55, P < 0.0001). Groups stratified by European League Against Rheumatism disease activity (DAS28-ESR ≤ 3.2, 3.2-5.1 and > 5.1) had significantly different MBDA scores (P < 0.0001) and MBDA score could discriminate ACR/EULAR Boolean remission with an area under the receiver operating characteristic curve of 0.83 (P < 0.0001).

Conclusion: The MBDA score reflects current clinical disease activity and can track changes in disease activity over time.

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U-PLEX Macrophage M1 Combo 1 (human) IL-1β, IL-6, IL-12p70, IL-18, IL-23, IP-10, MCP-1, MIP-1α, TNF-α \| Human Multiplex
Human Leptin Antibody Leptin \| Human
V-PLEX Metabolic Panel 1 Human Kit C-Peptide, GIP (active), GLP-1 (active), Glucagon, Insulin, Leptin, PP \| Human Multiplex
V-PLEX Plus Metabolic Panel 1 Human Kit C-Peptide, GIP (active), GLP-1 (active), Glucagon, Insulin, Leptin, PP \| Human Multiplex
V-PLEX Plus Human Leptin Kit Leptin \| Human Singleplex
V-PLEX Human Leptin Kit Leptin \| Human Singleplex
V-PLEX Viral Panel 3 NHP Kit IFN-γ, IL-1β, IL-5, IL-6, IL-8, IL-10 \| Non-human primate Multiplex
V-PLEX Viral Panel 3 Human Kit IFN-γ, IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-α \| Human Multiplex
V-PLEX Plus Viral Panel 3 NHP Kit IFN-γ, IL-1β, IL-5, IL-6, IL-8, IL-10 \| Non-human primate Multiplex
V-PLEX Plus Viral Panel 3 Human Kit IFN-γ, IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-α \| Human Multiplex
U-PLEX Viral Combo 1 (NHP) G-CSF, GM-CSF, IFN-α2a, IFN-γ, IL-1β, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IP-10, MCP-1, MIP-1α, TNF-α, VEGF-A \| Non-human primate Multiplex
U-PLEX Viral Combo 1 (human) G-CSF, GM-CSF, IFN-α2a, IFN-β, IFN-γ, IL-1β, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IP-10, MCP-1, MIP-1α, TNF-α, VEGF-A \| Human Multiplex
V-PLEX Viral Panel 1 NHP Kit IL-1β, IL-6, IL-8 \| Non-human primate Multiplex
V-PLEX Viral Panel 1 Human Kit IL-1β, IL-6, IL-8, TNF-α \| Human Multiplex
V-PLEX Plus Viral Panel 2 NHP Kit IFN-γ, IL-1β, IL-6, IL-8, IL-10 \| Non-human primate Multiplex
V-PLEX Plus Viral Panel 2 Human Kit IFN-γ, IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α \| Human Multiplex
V-PLEX Plus Viral Panel 1 NHP Kit IL-1β, IL-6, IL-8 \| Non-human primate Multiplex
V-PLEX Plus Viral Panel 1 Human Kit IL-1β, IL-6, IL-8, TNF-α \| Human Multiplex
V-PLEX Viral Panel 2 NHP Kit IFN-γ, IL-1β, IL-6, IL-8, IL-10 \| Non-human primate Multiplex
V-PLEX Viral Panel 2 Human Kit IFN-γ, IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α \| Human Multiplex
U-PLEX Rat Leptin Assay Leptin \| Rat Singleplex
U-PLEX Mouse Leptin Assay Leptin \| Mouse Singleplex
U-PLEX Human Leptin Assay Leptin \| Human Singleplex
U-PLEX NHP IL-6 Assay IL-6 \| Non-human primate Singleplex
U-PLEX Mouse IL-6 Assay IL-6 \| Mouse Singleplex
U-PLEX Human YKL-40 Assay YKL-40 \| Human Singleplex
U-PLEX Human IL-6 Assay IL-6 \| Human Singleplex
U-PLEX NHP YKL-40 Assay YKL-40 \| Non-human primate Singleplex
U-PLEX Mouse TNF-RI Assay TNF-RI \| Mouse Singleplex
R-PLEX Human MMP-3 Assay MMP-3 (total) \| Human Singleplex
R-PLEX Rat IL-6 Assay IL-6 \| Rat Singleplex
R-PLEX Human Resistin Assay Resistin \| Human Singleplex
R-PLEX Mouse Resistin Assay Resistin \| Mouse, Rat Singleplex
R-PLEX Human EGF Assay EGF \| Human Singleplex
R-PLEX Mouse MMP-3 (total) Assay MMP-3 (total) \| Mouse Singleplex
R-PLEX Mouse CRP Assay CRP \| Mouse Singleplex
R-PLEX Mouse SAA Assay SAA \| Mouse Singleplex
U-PLEX Custom Metabolic Group 1 (rat) Assays Rat Multiplex
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A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study.

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