Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns.

Martin CR, Bellomy M, Allred EN, Fichorova RN, Leviton A.
Journal   J Child Neurol.
Species  
Analytes Measured   CRP , E-Selectin , I-TAC , ICAM-1 , ICAM-3 , IGFBP-1 , IL-6 , IL-6R , IL-8 , MCP-1 , MCP-4 , MMP-1 , MMP-9 , MPO , RANTES , SAA , TNF-RI , TNF-RII , VCAM-1 , Flt-1 VEGFR1
Matrix Tested   Dried blood spots
Year   2012
Volume  
Page Numbers  
Application   Cytokines and Chemokines
Abstract
To define the role of systemic inflammation in infants with intestinal perforation (IP) and necrotizing enterocolitis (NEC), we measured 25 blood protein concentrations on days 1, 7 and 14 in 939 infants born before 28 weeks' gestation. On days 7 and 14, infants with NEC had elevated levels of C-reactive protein (CRP), serum amyloid A (SAA), IL-6 and IL-8. Infants with IP had elevated levels of CRP and insulin growth factor binding protein-1 on day 7 and elevated CRP, SAA, TNF-receptor-2 and matrix metalloproteinase-9 levels on day 14. A better understanding of systemic inflammation might help prevent and treat these disorders.

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