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Development of electrochemiluminescence-based singleplex and multiplex assays for the quantification of α-synuclein and other proteins in cerebrospinal fluid.
Development of electrochemiluminescence-based singleplex and multiplex assays for the quantification of α-synuclein and other proteins in cerebrospinal fluid.
Kruse N, Schulz-Schaeffer WJ, Schlossmacher MG, Mollenhauer B.
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Journal
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Methods.
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Species
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Analytes Measured
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Matrix Tested
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Cerebrospinal fluid (CSF)
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Year
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2012
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Volume
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56
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Page Numbers
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514-518
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Application
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Alzheimers
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Abstract
The need for improved diagnostic accuracy and markers of progression in neurodegenerative diseases motivates the identification of objective biomarkers as well as optimized assays for their quantification. Several potential marker candidates for Parkinson's disease (PD) in cerebrospinal fluid have been identified. These include α-synuclein, a major constituent of the intracellular aggregates. We give a general overview and details of our experience in converting established enzyme-linked immunoabsorbent assays (for α-synuclein and other proteins) onto an electrochemiluminescence-based platform as well as considerations on multiplexing different assays for PD.
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