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Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
Grathwohl, S.A., Kälin, R.E., Bolmont, T., Prokop, S., Winkelmann, G., Kaeser, S.A., Odenthal, J., Radde, R., Eldh, T., Gandy, S., Aguzzi, A., Staufenbiel, M., Mathews, P.M., Wolburg,H., Heppner, F.L., Jucker, M.
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Journal
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Nat Neurosci.
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Species
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Analytes Measured
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,
,
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Matrix Tested
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Brain homogenates (transgenics)
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Year
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2009
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Volume
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12
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Page Numbers
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1361-3
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Application
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Alzheimers
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Abstract
In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.
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