Decrease of circulating SAA is correlated with reduction of abdominal SAA secretion during weight loss.

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Decrease of circulating SAA is correlated with reduction of abdominal SAA secretion during weight loss.

Yang RZ, Blumenthal JB, Glynn NM, Lee MJ, Goldberg AP, Gong DW, Ryan AS.

Journal		Obesity
Species
Analytes Measured		SAA
Matrix Tested		Cell culture media

Year		2013
Volume
Page Numbers
Application		Angiogenesis and Vascular

Abstract

OBJECTIVE: The study goal was to determine the effect of weight loss (WL) alone and with aerobic exercise (WL + AEX) on serum amyloid A (SAA) levels and adipose SAA secretion from gluteal and abdominal depots.

DESIGN AND METHODS: Ninety-six overweight or obese postmenopausal women undertook a 6-month WL alone (n = 47) or with AEX training (n = 49) (6 months WL and WL + AEX are considered WL when groups were combined). Their serum SAA levels, body weight, and adipose SAA secretion ex vivo from gluteal and abdominal depot were measured before and after WL interventions.

RESULTS: The participants lost an average of 8% body weight with a 10% decrease of serum SAA. Serum SAA levels remained significantly correlated with body weight before and after WL. However, the changes of serum SAA level did not correlate with changes of body weight. The gluteal adipose tissue secreted ∼50% more SAA than the abdominal tissue, but the changes of abdominal, but not gluteal, SAA secretion correlated (R2 = 0.19, p < 0.01) with those of serum SAA levels during WL.

CONCLUSIONS: No linear correlation between the decrease in systemic SAA and WL was found. There is a depot-dependent difference in adipose SAA secretion and abdominal SAA secretion, which may partially account for the systemic SAA reduction during WL.

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Decrease of circulating SAA is correlated with reduction of abdominal SAA secretion during weight loss.

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