Home
>
References
>
2007
>
Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor.
Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor.
Poitout, L., Brault, V., Sackur, C., Bernetiere, S., Camara, J., Plas, P., Roubert, P.
|
Journal
|
|
Bioorg Med Chem Lett
|
|
Species
|
|
|
|
Analytes Measured
|
|
cAMP
|
|
Matrix Tested
|
|
Cell lysates
|
Abstract
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood-brain barrier after intravenous dosing in rats.
View Publications
Browse Our Products
Customer Service/Orders
Scientific/Technical Support
Instrument Support
Company Headquarters