Hypoxia is a pathological condition in which either the whole body (generalized hypoxia) or a region of the body (tissue hypoxia) is deprived of oxygen. Tissue hypoxia commonly occurs in cancerous tumors when rapid growth causes the tumor to outgrow its blood supply resulting in regions with significantly lower oxygen concentrations. It is a negative prognostic and predictive factor, as it contributes to chemoresistance, radioresistance, angiogenesis, vasculogenesis, invasiveness, metastasis, altered metabolism, and genomic instability. Reliable markers for hypoxia represent both valuable diagnostic markers and potential targets for investigation.

 

MSD provides solutions to support and simplify your hypoxia research needs. We offer singleplex and multiplex assays to measure biomarkers such as EPO, HIF-1α, IGFBP-1, and VEGF-A.

• Human
• Mouse
• Rat
• All Species

Title	Journal	Year
Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea Doufas AG, Tian L, Padrez KA, Suwanprathes P, Cardell JA, Maecker HT, Panousis P.	PLoS One	2013
Controlled regulation of erythropoietin by primary cultured renal cells for renal failure induced anemia. Gyabaah K, Aboushwareb T, Guimaraes Souza N, Yamaleyeva L, Varner A, Wang HJ, Atala A, Yoo JJ.	J Urol.	2012